| Gene Symbol |
CLEC4C
|
| Entrez Gene |
170482
|
| Alt Symbol |
BDCA2, CD303, CLECSF11, CLECSF7, DLEC, HECL, PRO34150
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
C-type lectin domain family 4, member C
|
| Other Description |
BDCA-2|C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 11|C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 7|C-type lectin domain family 4 member C|C-type lectin superfamily member 7|blood dendritic cell antigen 2 protein|dendritic cell lectin b|dendritic lectin
|
| Swissprots |
Q8WXX8 Q6UXS8 Q8WTT0 Q3T1C3 D3DUU3
|
| Accessions |
EAW88654 EAW88655 EAW88656 Q8WTT0 AF293615 AAL37036 AF325459 AAL37358 AF325460 AAL37359 AK122596 BAG53616 AY358223 AAQ88590 BC074967 AAH74967 BC074968 AAH74968 BC102015 AAI02016 BC102016 AAI02017 BC102017 AAI02018 BC114338 AAI14339 NM_130441 NP_569708 NM_203503 NP_987099
|
| Function |
Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein- tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose. {ECO:0000269|PubMed:11031109, ECO:0000269|PubMed:11748283}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha. {ECO:0000269|PubMed:11031109, ECO:0000269|PubMed:11536172, ECO:0000269|PubMed:11748283}.
|