CLEC4C

Gene Symbol CLEC4C
Entrez Gene 170482
Alt Symbol BDCA2, CD303, CLECSF11, CLECSF7, DLEC, HECL, PRO34150
Species Human
Gene Type protein-coding
Description C-type lectin domain family 4, member C
Other Description BDCA-2|C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 11|C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 7|C-type lectin domain family 4 member C|C-type lectin superfamily member 7|blood dendritic cell antigen 2 protein|dendritic cell lectin b|dendritic lectin
Swissprots Q8WXX8 Q6UXS8 Q8WTT0 Q3T1C3 D3DUU3
Accessions EAW88654 EAW88655 EAW88656 Q8WTT0 AF293615 AAL37036 AF325459 AAL37358 AF325460 AAL37359 AK122596 BAG53616 AY358223 AAQ88590 BC074967 AAH74967 BC074968 AAH74968 BC102015 AAI02016 BC102016 AAI02017 BC102017 AAI02018 BC114338 AAI14339 NM_130441 NP_569708 NM_203503 NP_987099
Function Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein- tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose. {ECO:0000269|PubMed:11031109, ECO:0000269|PubMed:11748283}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha. {ECO:0000269|PubMed:11031109, ECO:0000269|PubMed:11536172, ECO:0000269|PubMed:11748283}.

Anti-CLEC4C / CD303 / BDCA-2 Antibody (aa5-183) - LS-C293565 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant CLEC4C / CD303 / BDCA-2.

Anti-CLEC4C / CD303 / BDCA-2 Antibody (Internal) - LS-C108101 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
CLEC4C antibody (1 ug/ml) staining of Human Spleen lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-CLEC4C antibody produced in rabbit - HPA029432 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CLEC4C: <B>Cat. No. HPA029432</B>: Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.

Anti-CLEC4C antibody produced in goat - SAB2501252 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CLEC4C: <B>Cat. No. SAB2501252</B>: (1 μg/mL) staining of Human Spleen lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

CLEC4C--BDCA2-Antibody-Internal-region - AF2955a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF2955a (1 µg/ml) staining of Human Spleen lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

CD303 antibody - GTX37364 from GeneTex

Prices $329.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Anti-CD303 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX37364

CD303 antibody, Internal - GTX88418 from GeneTex

Prices $319.00
Sizes 100 μg
Host Goat
Clonality Polyclonal
Anti-CLEC4C / BDCA2 antibody, Internal used in Western blot. GTX88418

Human DLEC/CLEC4C/BDCA-2 Antibody - AF1376 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Detection of DLEC/CLEC4C/BDCA-2 in Human Whole Blood by Flow Cytometry. Human whole blood were stained with Goat Anti- Human DLEC/CLEC4C/BDCA-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1376) followed by Allophycocyanin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0108 ) and Human IL-3 Ra Phycoerythrin-conjugated Monoclonal Antibody (Catalog # FAB301P ).Quadrant markers were set based on control antibody staining (Catalog # AB-108-C ).
Detection of DLEC/CLEC4C/BDCA‑2 in Human Whole Blood by Flow Cytometry. Human whole blood were stained with Goat Anti- Human DLEC/CLEC4C/BDCA‑2 Antigen Affinity‑purified Polyclonal Antibody (Catalog # AF1376) followed by Allophycocyanin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0108) and Human IL-3 R alpha Phycoerythrin-conjugated Monoclonal Antibody (Catalog # FAB301P).Quadrant markers were set based on control antibody staining (Catalog # AB-108-C).

Human DLEC/CLEC4C/BDCA-2 APC Affinity Purified PAb, Goat IgG - FAB1376A-025 from R&D Systems

Host Goat
Clonality Polyclonal
Detection of DLEC/CLEC4C/BDCA‑2 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human IL‑3 R alpha/CD123 PE‑conjugated Monoclonal Antibody (Catalog # FAB301P) and either (A) Goat Anti-Human DLEC/CLEC4C/BDCA‑2 APC‑conjugated Polyclonal Antibody (Catalog # FAB1376A) or (B) Normal Goat IgG Allophycocyanin Control (Catalog # IC108A). View our protocol for Staining Membrane-associated Proteins.

Human DLEC/CLEC4C/BDCA-2 APC Affinity Purified PAb, Goat IgG - FAB1376A-100 from R&D Systems

Host Goat
Clonality Polyclonal
Detection of DLEC/CLEC4C/BDCA‑2 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human IL‑3 R alpha/CD123 PE‑conjugated Monoclonal Antibody (Catalog # FAB301P) and either (A) Goat Anti-Human DLEC/CLEC4C/BDCA‑2 APC‑conjugated Polyclonal Antibody (Catalog # FAB1376A) or (B) Normal Goat IgG Allophycocyanin Control (Catalog # IC108A). View our protocol for Staining Membrane-associated Proteins.
Detection of DLEC/CLEC4C/BDCA‑2 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human IL‑3 R alpha/CD123 APC‑conjugated Monoclonal Antibody (Catalog # FAB301A) and either (A) Goat Anti-Human DLEC/CLEC4C/BDCA‑2 PE‑conjugated Polyclonal Antibody (Catalog # FAB1376P) or (B) Normal Goat IgG Phycoerythrin Control (Catalog # IC108P). View our protocol for Staining Membrane-associated Proteins.
Detection of DLEC/CLEC4C/BDCA‑2 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human IL‑3 R alpha/CD123 APC‑conjugated Monoclonal Antibody (Catalog # FAB301A) and either (A) Goat Anti-Human DLEC/CLEC4C/BDCA‑2 PE‑conjugated Polyclonal Antibody (Catalog # FAB1376P) or (B) Normal Goat IgG Phycoerythrin Control (Catalog # IC108P). View our protocol for Staining Membrane-associated Proteins.

Human DLEC/CLEC4C/BDCA-2 Biotinylated Antibody - BAF1376 from R&D Systems

Prices $390.00
Sizes 50 µg
Host Goat

CD303 antibody - orb13622 from Biorbyt

Prices $255.00, $340.00
Sizes 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal
IHC-P image of mouse lymph gland tissue using anti-CD303 (dilution of primary antibody at 1:100)

CD303 Antibody (OABI00016) - OABI00016 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Goat Anti-CLEC4C / BDCA2 Antibody (OAEB02188) - OAEB02188 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti -CLEC4C (BDCA2, C-type Lectin Domain Family 4, Member C) - C5839-60 from USBiological Life Science

Host Goat
Clonality Polyclonal

Anti -CLEC4C (BDCA2, C-type Lectin Domain Family 4, Member C) (AP) - C5839-60-AP from USBiological Life Science

Host Goat
Clonality Polyclonal

Anti -CLEC4C (BDCA2, C-type Lectin Domain Family 4, Member C) (APC) - C5839-60-APC from USBiological Life Science

Host Goat
Clonality Polyclonal

Anti -CLEC4C (BDCA2, C-type Lectin Domain Family 4, Member C) (Biotin) - C5839-60-Biotin from USBiological Life Science

Host Goat
Clonality Polyclonal

Anti -CLEC4C (BDCA2, C-type Lectin Domain Family 4, Member C) (FITC) - C5839-60-FITC from USBiological Life Science

Host Goat
Clonality Polyclonal

Anti -CLEC4C (BDCA2, C-type Lectin Domain Family 4, Member C) (HRP) - C5839-60-HRP from USBiological Life Science

Host Goat
Clonality Polyclonal

Anti -CLEC4C (BDCA2, C-type Lectin Domain Family 4, Member C) (PE) - C5839-60-PE from USBiological Life Science

Host Goat
Clonality Polyclonal

CD303 antibody (FITC) - orb14185 from Biorbyt

Prices $315.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
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