| Gene Symbol | ARHGDIG |
|---|---|
| Entrez Gene | 398 |
| Alt Symbol | RHOGDI-3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Rho GDP dissociation inhibitor (GDI) gamma |
| Other Description | RhoGDI gamma|rho GDI 3|rho GDP-dissociation inhibitor 3|rho-GDI gamma |
| Swissprots | Q99819 Q96S29 Q4TT69 |
| Accessions | AAC72354 AAK61222 CAI95584 CAI95585 CAM26353 EAW85837 Q99819 AB593111 BAJ84051 AF498928 AAM21076 BC047699 AAH47699 BM662457 BU732723 U82532 AAC33138 NM_001176 NP_001167 |
| Function | Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Primarily expressed in pancreas and brain. |
| Top Pathways | Neurotrophin signaling pathway, Vasopressin-regulated water reabsorption |