| Gene Symbol |
ARHGDIG
|
| Entrez Gene |
398
|
| Alt Symbol |
RHOGDI-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rho GDP dissociation inhibitor (GDI) gamma
|
| Other Description |
RhoGDI gamma|rho GDI 3|rho GDP-dissociation inhibitor 3|rho-GDI gamma
|
| Swissprots |
Q99819 Q96S29 Q4TT69
|
| Accessions |
AAC72354 AAK61222 CAI95584 CAI95585 CAM26353 EAW85837 Q99819 AB593111 BAJ84051 AF498928 AAM21076 BC047699 AAH47699 BM662457 BU732723 U82532 AAC33138 NM_001176 NP_001167
|
| Function |
Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Primarily expressed in pancreas and brain.
|
| Top Pathways |
Neurotrophin signaling pathway, Vasopressin-regulated water reabsorption
|