Gene Symbol | GHR |
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Entrez Gene | 2690 |
Alt Symbol | GHBP, GHIP |
Species | Human |
Gene Type | protein-coding |
Description | growth hormone receptor |
Other Description | GH receptor|growth hormone binding protein|serum binding protein|somatotropin receptor |
Swissprots | Q9HCX2 P10912 |
Accessions | AAA52555 AAB34503 AAF71399 CAC06613 CAC06615 CAH05763 CAM36317 CBJ05777 CBJ21229 CDM63320 EAW56023 P10912 AF230800 AF230801 BC136496 AAI36497 BM719293 BU625645 S97393 AAD15015 X06562 CAA29808 Z11801 CAA77845 Z11802 CAA77846 Z11848 CAA77872 Z11849 CAA77873 Z11850 CAA77874 Z11851 CAA77875 Z11853 CAA77877 XM_011514031 XP_011512333 NM_000163 NP_000154 NM_001242399 NP_001229328 NM_001242400 NP_001229329 NM_001242401 NP_001229330 NM_001242402 NP_001229331 NM_001242403 NP_001229332 NM_001242404 NP_001229333 NM_001242405 NP_001229334 NM_001242406 NP_001229335 NM_001242460 NP_001229389 NM_001242462 NP_001229391 NM_001242461 |
Function | Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. |
Subcellular Location | Growth hormone-binding protein: Secreted. Note=Complexed to a substantial fraction of circulating GH. {ECO:0000250}. |
Tissue Specificity | Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, PI3K-Akt signaling pathway, Neuroactive ligand-receptor interaction |
GHR (B-10) - sc-137185 from Santa Cruz Biotechnology
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GHR (MAB 7) - sc-69882 from Santa Cruz Biotechnology
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GHR (B-12) - sc-137184 from Santa Cruz Biotechnology
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GHR (MAB 43) - sc-69881 from Santa Cruz Biotechnology
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GHR (MAB 5) - sc-69880 from Santa Cruz Biotechnology
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GHR (S-16) - sc-10351 from Santa Cruz Biotechnology
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GHR (MAB 1) - sc-69883 from Santa Cruz Biotechnology
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GHR (L-16) - sc-10352 from Santa Cruz Biotechnology
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GHR (H-300) - sc-20747 from Santa Cruz Biotechnology
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GHR (MAB 263) - sc-57161 from Santa Cruz Biotechnology
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GHR (3H2186) - sc-71146 from Santa Cruz Biotechnology
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Anti-Growth hormone receptor antibody - ab65304 from Abcam
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Anti-Growth hormone receptor antibody [B767M] - ab130857 from Abcam
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Anti-Growth hormone receptor antibody [EPR5291(2)] - ab134078 from Abcam
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Anti-Growth hormone receptor antibody [MAB 263] - ab11380 from Abcam
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Anti-Growth hormone receptor antibody [MM0320-6J33] - ab89304 from Abcam
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Anti-Growth hormone receptor antibody [MM0321-3C59] - ab89400 from Abcam
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Anti-Growth hormone receptor antibody - C-terminal - ab179653 from Abcam
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Anti-Growth Hormone Receptor / GHR Antibody (N-Terminus, Magnetic beads) - LS-C171953 from LifeSpan Bioscience
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Anti-Growth Hormone Receptor / GHR Antibody (N-Terminus, Sepharose) - LS-C171954 from LifeSpan Bioscience
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Anti-Growth Hormone Receptor / GHR Antibody (aa36-266, Biotin) - LS-C298791 from LifeSpan Bioscience
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Anti-Growth Hormone Receptor / GHR Antibody (aa36-266, FITC) - LS-C302964 from LifeSpan Bioscience
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Anti-Growth Hormone Receptor / GHR Antibody (aa231-247) - LS-C312877 from LifeSpan Bioscience
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Anti-Growth Hormone Receptor / GHR Antibody (aa36-85) - LS-C110871 from LifeSpan Bioscience
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Anti-Growth Hormone Receptor / GHR Antibody (clone 3A12) - LS-C197294 from LifeSpan Bioscience
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