Gene Symbol | GHR |
---|---|
Entrez Gene | 2690 |
Alt Symbol | GHBP, GHIP |
Species | Human |
Gene Type | protein-coding |
Description | growth hormone receptor |
Other Description | GH receptor|growth hormone binding protein|serum binding protein|somatotropin receptor |
Swissprots | Q9HCX2 P10912 |
Accessions | AAA52555 AAB34503 AAF71399 CAC06613 CAC06615 CAH05763 CAM36317 CBJ05777 CBJ21229 CDM63320 EAW56023 P10912 AF230800 AF230801 BC136496 AAI36497 BM719293 BU625645 S97393 AAD15015 X06562 CAA29808 Z11801 CAA77845 Z11802 CAA77846 Z11848 CAA77872 Z11849 CAA77873 Z11850 CAA77874 Z11851 CAA77875 Z11853 CAA77877 XM_011514031 XP_011512333 NM_000163 NP_000154 NM_001242399 NP_001229328 NM_001242400 NP_001229329 NM_001242401 NP_001229330 NM_001242402 NP_001229331 NM_001242403 NP_001229332 NM_001242404 NP_001229333 NM_001242405 NP_001229334 NM_001242406 NP_001229335 NM_001242460 NP_001229389 NM_001242462 NP_001229391 NM_001242461 |
Function | Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. |
Subcellular Location | Growth hormone-binding protein: Secreted. Note=Complexed to a substantial fraction of circulating GH. {ECO:0000250}. |
Tissue Specificity | Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, PI3K-Akt signaling pathway, Neuroactive ligand-receptor interaction |
GHR CRISPR/Cas9 KO Plasmid (h) - sc-401382 from Santa Cruz Biotechnology
|
||||||||
GHR HDR Plasmid (h) - sc-401382-HDR from Santa Cruz Biotechnology
|
||||||||
GHR Double Nickase Plasmid (h) - sc-401382-NIC from Santa Cruz Biotechnology
|
||||||||
GHR Double Nickase Plasmid (h2) - sc-401382-NIC-2 from Santa Cruz Biotechnology
|
||||||||
GHR CRISPR Activation Plasmid (h) - sc-401382-ACT from Santa Cruz Biotechnology
|
||||||||
GHR CRISPR Activation Plasmid (h2) - sc-401382-ACT-2 from Santa Cruz Biotechnology
|
||||||||
GHR Lentiviral Activation Particles (h) - sc-401382-LAC from Santa Cruz Biotechnology
|
||||||||
GHR Lentiviral Activation Particles (h2) - sc-401382-LAC-2 from Santa Cruz Biotechnology
|
||||||||
GHR siRNA (h) - sc-40015 from Santa Cruz Biotechnology
|
||||||||
GHR shRNA Plasmid (h) - sc-40015-SH from Santa Cruz Biotechnology
|
||||||||
GHR shRNA (h) Lentiviral Particles - sc-40015-V from Santa Cruz Biotechnology
|
||||||||
Growth Hormone R RNAi - H00002690-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU060521 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN9275 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9275 from Sigma-Aldrich
|
||||||||
GHR siRNA (Human) - CRH1793 from Cohesion Biosciences
|
||||||||
GHR - MBS8229259 from MyBioSource
|
||||||||
shRNA set against Human Ghr (NM_000163.4) - SHH300966 from Creative biogene
|
||||||||
Human GHR siRNA - orb262295 from Biorbyt
|
||||||||
GHR shRNA Plasmid (Human) - CHH1793 from Cohesion Biosciences
|