| Gene Symbol |
PKP3
|
| Entrez Gene |
11187
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
plakophilin 3
|
| Other Description |
plakophilin 3b|plakophilin-3
|
| Swissprots |
Q53EX8 Q9Y446 F8J390
|
| Accessions |
EAX02322 EAX02323 Q9Y446 AF053719 AAF23050 AK025067 AK223511 BAD97231 BC000081 AAH00081 BG611119 BX356582 CA947983 DB139782 DQ891692 ABM82618 DQ894875 ABM85801 FN421477 CAZ65731 Z98265 CAB44310 NM_001303029 NP_001289958 NM_007183 NP_009114
|
| Function |
May play a role in junctional plaques.
|
| Subcellular Location |
Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes.
|
| Tissue Specificity |
Isoform PKP3a is found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. Isoform PKP3b is abundant in the desmosomes of stratified epithelial cell but absent in simple epithelial cells, it is also expressed in the colon and its tumors. {ECO:0000269|PubMed:24178805}.
|