Gene Symbol | PKP3 |
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Entrez Gene | 11187 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | plakophilin 3 |
Other Description | plakophilin 3b|plakophilin-3 |
Swissprots | Q53EX8 Q9Y446 F8J390 |
Accessions | EAX02322 EAX02323 Q9Y446 AF053719 AAF23050 AK025067 AK223511 BAD97231 BC000081 AAH00081 BG611119 BX356582 CA947983 DB139782 DQ891692 ABM82618 DQ894875 ABM85801 FN421477 CAZ65731 Z98265 CAB44310 NM_001303029 NP_001289958 NM_007183 NP_009114 |
Function | May play a role in junctional plaques. |
Subcellular Location | Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes. |
Tissue Specificity | Isoform PKP3a is found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. Isoform PKP3b is abundant in the desmosomes of stratified epithelial cell but absent in simple epithelial cells, it is also expressed in the colon and its tumors. {ECO:0000269|PubMed:24178805}. |
plakophilin 3 CRISPR/Cas9 KO Plasmid (h) - sc-403614 from Santa Cruz Biotechnology
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plakophilin 3 HDR Plasmid (h) - sc-403614-HDR from Santa Cruz Biotechnology
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plakophilin 3 Double Nickase Plasmid (h) - sc-403614-NIC from Santa Cruz Biotechnology
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plakophilin 3 Double Nickase Plasmid (h2) - sc-403614-NIC-2 from Santa Cruz Biotechnology
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plakophilin 3 CRISPR Activation Plasmid (h) - sc-403614-ACT from Santa Cruz Biotechnology
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plakophilin 3 CRISPR Activation Plasmid (h2) - sc-403614-ACT-2 from Santa Cruz Biotechnology
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plakophilin 3 Lentiviral Activation Particles (h) - sc-403614-LAC from Santa Cruz Biotechnology
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plakophilin 3 Lentiviral Activation Particles (h2) - sc-403614-LAC-2 from Santa Cruz Biotechnology
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plakophilin 3 siRNA (h) - sc-62826 from Santa Cruz Biotechnology
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plakophilin 3 shRNA Plasmid (h) - sc-62826-SH from Santa Cruz Biotechnology
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plakophilin 3 shRNA (h) Lentiviral Particles - sc-62826-V from Santa Cruz Biotechnology
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Plakophilin-3 RNAi - H00011187-R02 from Novus Biologicals
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Plakophilin-3 RNAi - H00011187-R01 from Novus Biologicals
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MISSION® esiRNA - EHU132181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16878 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16878 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02627 from Sigma-Aldrich
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PKP3 siRNA (Human) - CRH7667 from Cohesion Biosciences
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shRNA set against Human PKP3 (NM_007183.2) - SHH376620 from Creative biogene
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Human PKP3 siRNA - orb268169 from Biorbyt
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PKP3 shRNA Plasmid (Human) - CHH7667 from Cohesion Biosciences
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PKP3 miRNA 3'UTR clone - MiUTR1H-07950 from Creative biogene
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