| Gene Symbol |
LY75
|
| Entrez Gene |
4065
|
| Alt Symbol |
CD205, CLEC13B, DEC-205, GP200-MR6, LY-75
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lymphocyte antigen 75
|
| Other Description |
C-type lectin domain family 13 member B
|
| Swissprots |
Q53TF5 Q53R46 O60449 Q7Z575 O75913 Q7Z577
|
| Accessions |
AAY14943 AAY24189 CCQ43175 O60449 AA279177 AB208915 BAD92152 AF011333 AAC17636 AF064827 AAC62622 AK310678 AU099700 BC057232 BC172265 AAI72265 DB135177 DB146492 DB150194 NM_002349 NP_002340
|
| Function |
Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes. {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells. {ECO:0000269|PubMed:12824192, ECO:0000269|PubMed:9862343}.
|