Gene Symbol | LY75 |
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Entrez Gene | 4065 |
Alt Symbol | CD205, CLEC13B, DEC-205, GP200-MR6, LY-75 |
Species | Human |
Gene Type | protein-coding |
Description | lymphocyte antigen 75 |
Other Description | C-type lectin domain family 13 member B |
Swissprots | Q53TF5 Q53R46 O60449 Q7Z575 O75913 Q7Z577 |
Accessions | AAY14943 AAY24189 CCQ43175 O60449 AA279177 AB208915 BAD92152 AF011333 AAC17636 AF064827 AAC62622 AK310678 AU099700 BC057232 BC172265 AAI72265 DB135177 DB146492 DB150194 NM_002349 NP_002340 |
Function | Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes. {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells. {ECO:0000269|PubMed:12824192, ECO:0000269|PubMed:9862343}. |
DEC-205 CRISPR/Cas9 KO Plasmid (h) - sc-417220 from Santa Cruz Biotechnology
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DEC-205 HDR Plasmid (h) - sc-417220-HDR from Santa Cruz Biotechnology
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DEC-205 Double Nickase Plasmid (h) - sc-417220-NIC from Santa Cruz Biotechnology
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DEC-205 Double Nickase Plasmid (h2) - sc-417220-NIC-2 from Santa Cruz Biotechnology
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DEC-205 CRISPR Activation Plasmid (h) - sc-417220-ACT from Santa Cruz Biotechnology
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DEC-205 CRISPR Activation Plasmid (h2) - sc-417220-ACT-2 from Santa Cruz Biotechnology
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DEC-205 Lentiviral Activation Particles (h) - sc-417220-LAC from Santa Cruz Biotechnology
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DEC-205 Lentiviral Activation Particles (h2) - sc-417220-LAC-2 from Santa Cruz Biotechnology
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DEC-205 siRNA (h) - sc-42860 from Santa Cruz Biotechnology
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DEC-205 shRNA Plasmid (h) - sc-42860-SH from Santa Cruz Biotechnology
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DEC-205 shRNA (h) Lentiviral Particles - sc-42860-V from Santa Cruz Biotechnology
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Renal Cell Carcinoma (gp200) RNAi - H00004065-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN12843 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12843 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10061 from Sigma-Aldrich
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LY75 siRNA (Human) - CRH2754 from Cohesion Biosciences
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DEC-205 CRISPR/Cas9 KO Plasmid (h2) - sc-417220-KO-2 from Santa Cruz Biotechnology
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DEC-205 HDR Plasmid (h2) - sc-417220-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human LY75 (NM_002349.3) - SHH335895 from Creative biogene
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LY75 shRNA Plasmid (Human) - CHH2754 from Cohesion Biosciences
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LY75 miRNA 3'UTR clone - MiUTR3H-06887 from Creative biogene
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