| Gene Symbol |
KPNA6
|
| Entrez Gene |
23633
|
| Alt Symbol |
IPOA7, KPNA7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
karyopherin alpha 6 (importin alpha 7)
|
| Other Description |
importin alpha 7 subunit|importin subunit alpha-7|importin-alpha-S2|karyopherin subunit alpha-6
|
| Swissprots |
Q5VVU3 B2RDC7 D3DPP5 O60684
|
| Accessions |
EAX07567 EAX07568 EAX07569 O60684 AB621806 BAK64142 AF060543 AAC15233 AK000724 AK002111 AK128609 AK295615 BAG58497 AK301714 BAG63185 AK315490 BAG37874 AU142228 BC020520 AAH20520 BP374991 BT009843 AAP88845 DQ891587 ABM82513 DQ894781 ABM85707 XM_005270711 XP_005270768 XM_011541160 XP_011539462 NM_012316 NP_036448
|
| Function |
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:10523667}.
|