Gene Symbol | KPNA6 |
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Entrez Gene | 23633 |
Alt Symbol | IPOA7, KPNA7 |
Species | Human |
Gene Type | protein-coding |
Description | karyopherin alpha 6 (importin alpha 7) |
Other Description | importin alpha 7 subunit|importin subunit alpha-7|importin-alpha-S2|karyopherin subunit alpha-6 |
Swissprots | Q5VVU3 B2RDC7 D3DPP5 O60684 |
Accessions | EAX07567 EAX07568 EAX07569 O60684 AB621806 BAK64142 AF060543 AAC15233 AK000724 AK002111 AK128609 AK295615 BAG58497 AK301714 BAG63185 AK315490 BAG37874 AU142228 BC020520 AAH20520 BP374991 BT009843 AAP88845 DQ891587 ABM82513 DQ894781 ABM85707 XM_005270711 XP_005270768 XM_011541160 XP_011539462 NM_012316 NP_036448 |
Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10523667}. |
Human KPNA6 full length protein - ab161726 from Abcam
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KPNA6 Antibody Blocking Peptide - LS-E31007 from LifeSpan Bioscience
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KPNA6 Antibody Blocking Peptide - LS-E26717 from LifeSpan Bioscience
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KPNA6 Antibody Blocking Peptide - LS-E19788 from LifeSpan Bioscience
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KPNA7 Antibody Blocking Peptide - LS-E31008 from LifeSpan Bioscience
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KPNA7 Antibody Blocking Peptide - LS-E24328 from LifeSpan Bioscience
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KPNA6 Recombinant Protein - H00023633-P01 from Novus Biologicals
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KPNA6 Peptide - NBP1-76301PEP from Novus Biologicals
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KPNA6-Antibody-C-term-Blocking-peptide - BP12228b from Abgent, a WuXi AppTec company
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KPNA6 blocking peptide - GTX88712-PEP from GeneTex
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KPNA6 Peptide - AC21-1556-P from Abcore
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KPNA6 / Importin alpha-7 - H00023633-P01-10 from Acris Antibodies
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KPNA6 / Importin alpha-7 - H00023633-P01-25 from Acris Antibodies
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KPNA6 / Importin alpha-7 control peptide - AP26277CP-N from Acris Antibodies
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KPNA6 / Importin alpha-7 (N-term) Control Peptide - AP55453CP-N from Acris Antibodies
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KPNA6 Peptide - 46-860P from ProSci
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KPNA6 Peptide - 5991P from ProSci
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KPNA6 fusion protein - Ag3040 from Proteintech Group
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Recombinant Human Importin subunit alpha-7(KPNA6) - CSB-YP012488HU CSB-EP012488HU CSB-BP012488HU CSB-MP012488HU from Cusabio
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KPNA6 Protein - abx164042 from Abbexa
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KPNA6 / Importin alpha-7 - TP303926 from Acris Antibodies
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KPNA6, Peptide - MBS425068 from MyBioSource
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KPNA7 Recombinant Protein Antigen - NBP1-91014PEP from Novus Biologicals
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KPNA6 Recombinant Protein Antigen - NBP1-83762PEP from Novus Biologicals
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KPNA6 Peptide, Human - M34GP08341H from Creative Peptides
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