| Gene Symbol |
KIF5A
|
| Entrez Gene |
3798
|
| Alt Symbol |
D12S1889, MY050, NKHC, SPG10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kinesin family member 5A
|
| Other Description |
KIF5A variant protein|kinesin heavy chain isoform 5A|kinesin heavy chain neuron-specific 1|kinesin, heavy chain, neuron-specific|neuronal kinesin heavy chain
|
| Swissprots |
A6H8M5 Q4LE26 Q12840
|
| Accessions |
EAW97030 Q12840 AB210045 BAE06127 AB290174 BAG06728 AF063608 AAG43166 AK294881 BAH11913 AK315202 BAG37640 AL118561 AL707807 BC033961 BC035285 BC051752 BC140009 AAI40010 BC146670 AAI46671 BC150208 AAI50209 BM930000 U06698 AAA20231 NM_004984 NP_004975
|
| Function |
Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region. {ECO:0000250}.
|
| Tissue Specificity |
Distributed throughout the CNS but is highly enriched in subsets of neurons.
|
| Top Pathways |
Dopaminergic synapse
|