Gene Symbol | KIF5A |
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Entrez Gene | 3798 |
Alt Symbol | D12S1889, MY050, NKHC, SPG10 |
Species | Human |
Gene Type | protein-coding |
Description | kinesin family member 5A |
Other Description | KIF5A variant protein|kinesin heavy chain isoform 5A|kinesin heavy chain neuron-specific 1|kinesin, heavy chain, neuron-specific|neuronal kinesin heavy chain |
Swissprots | A6H8M5 Q4LE26 Q12840 |
Accessions | EAW97030 Q12840 AB210045 BAE06127 AB290174 BAG06728 AF063608 AAG43166 AK294881 BAH11913 AK315202 BAG37640 AL118561 AL707807 BC033961 BC035285 BC051752 BC140009 AAI40010 BC146670 AAI46671 BC150208 AAI50209 BM930000 U06698 AAA20231 NM_004984 NP_004975 |
Function | Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). {ECO:0000250}. |
Subcellular Location | Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region. {ECO:0000250}. |
Tissue Specificity | Distributed throughout the CNS but is highly enriched in subsets of neurons. |
Top Pathways | Dopaminergic synapse |
NKHC1 CRISPR/Cas9 KO Plasmid (h) - sc-405443 from Santa Cruz Biotechnology
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NKHC1 HDR Plasmid (h) - sc-405443-HDR from Santa Cruz Biotechnology
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NKHC1 Double Nickase Plasmid (h) - sc-405443-NIC from Santa Cruz Biotechnology
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NKHC1 Double Nickase Plasmid (h2) - sc-405443-NIC-2 from Santa Cruz Biotechnology
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NKHC1 CRISPR Activation Plasmid (h) - sc-405443-ACT from Santa Cruz Biotechnology
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NKHC1 CRISPR Activation Plasmid (h2) - sc-405443-ACT-2 from Santa Cruz Biotechnology
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NKHC1 Lentiviral Activation Particles (h) - sc-405443-LAC from Santa Cruz Biotechnology
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NKHC1 Lentiviral Activation Particles (h2) - sc-405443-LAC-2 from Santa Cruz Biotechnology
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NKHC1 siRNA (h) - sc-36073 from Santa Cruz Biotechnology
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NKHC1 shRNA Plasmid (h) - sc-36073-SH from Santa Cruz Biotechnology
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NKHC1 shRNA (h) Lentiviral Particles - sc-36073-V from Santa Cruz Biotechnology
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Kinesin 5A RNAi - H00003798-R01 from Novus Biologicals
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MISSION® esiRNA - EHU024751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11204 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11204 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04342 from Sigma-Aldrich
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KIF5A siRNA (Human) - CRH2569 from Cohesion Biosciences
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shRNA set against Human KIF5A (NM_004984.2) - SHH325347 from Creative biogene
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shRNA set against Human KIF5A(NM_004984.2) - SHL197352 from Creative biogene
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Human KIF5A siRNA - orb263071 from Biorbyt
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KIF5A shRNA Plasmid (Human) - CHH2569 from Cohesion Biosciences
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KIF5A miRNA 3'UTR clone - MiUTR1H-05315 from Creative biogene
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