Gene Symbol |
IL1F10
|
Entrez Gene |
84639
|
Alt Symbol |
FIL1-theta, FKSG75, IL-1HY2, IL-38, IL1-theta, IL1HY2
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
interleukin 1 family, member 10 (theta)
|
Other Description |
FIL1 theta|IL-1 theta|IL-1F10 (canonical form IL-1F10a)|family of interleukin 1-theta|interleukin-1 HY2|interleukin-1 family member 10|interleukin-1 receptor antagonist FKSG75|interleukin-1 receptor antagonist-like FIL1 theta|interleukin-38
|
Swissprots |
Q53SR9 Q7RTZ5 Q9BYX1 Q969H5 Q56AT8 Q8WWZ1
|
Accessions |
AAK68049 AAX59032 AAY14991 CAD29878 EAW73619 EAW73620 Q8WWZ1 AF334755 AAK68048 AY026753 AAK01948 AY029413 AAK33010 AY358846 AAQ89205 BC103966 AAI03967 BC103967 AAI03968 BC103968 AAI03969 NM_032556 NP_115945 NM_173161 NP_775184
|
Function |
Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2. {ECO:0000269|PubMed:22315422}.
|
Subcellular Location |
Secreted.
|
Tissue Specificity |
Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.
|