Gene Symbol | IL1F10 |
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Entrez Gene | 84639 |
Alt Symbol | FIL1-theta, FKSG75, IL-1HY2, IL-38, IL1-theta, IL1HY2 |
Species | Human |
Gene Type | protein-coding |
Description | interleukin 1 family, member 10 (theta) |
Other Description | FIL1 theta|IL-1 theta|IL-1F10 (canonical form IL-1F10a)|family of interleukin 1-theta|interleukin-1 HY2|interleukin-1 family member 10|interleukin-1 receptor antagonist FKSG75|interleukin-1 receptor antagonist-like FIL1 theta|interleukin-38 |
Swissprots | Q53SR9 Q7RTZ5 Q9BYX1 Q969H5 Q56AT8 Q8WWZ1 |
Accessions | AAK68049 AAX59032 AAY14991 CAD29878 EAW73619 EAW73620 Q8WWZ1 AF334755 AAK68048 AY026753 AAK01948 AY029413 AAK33010 AY358846 AAQ89205 BC103966 AAI03967 BC103967 AAI03968 BC103968 AAI03969 NM_032556 NP_115945 NM_173161 NP_775184 |
Function | Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2. {ECO:0000269|PubMed:22315422}. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil. |
IL-1F10 CRISPR/Cas9 KO Plasmid (h) - sc-410201 from Santa Cruz Biotechnology
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IL-1F10 HDR Plasmid (h) - sc-410201-HDR from Santa Cruz Biotechnology
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IL-1F10 Double Nickase Plasmid (h) - sc-410201-NIC from Santa Cruz Biotechnology
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IL-1F10 Double Nickase Plasmid (h2) - sc-410201-NIC-2 from Santa Cruz Biotechnology
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IL-1F10 CRISPR Activation Plasmid (h) - sc-410201-ACT from Santa Cruz Biotechnology
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IL-1F10 CRISPR Activation Plasmid (h2) - sc-410201-ACT-2 from Santa Cruz Biotechnology
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IL-1F10 Lentiviral Activation Particles (h) - sc-410201-LAC from Santa Cruz Biotechnology
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IL-1F10 Lentiviral Activation Particles (h2) - sc-410201-LAC-2 from Santa Cruz Biotechnology
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IL-1F10 siRNA (h) - sc-94570 from Santa Cruz Biotechnology
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IL-1F10 shRNA Plasmid (h) - sc-94570-SH from Santa Cruz Biotechnology
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IL-1F10 shRNA (h) Lentiviral Particles - sc-94570-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN10590 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10590 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03939 from Sigma-Aldrich
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IL1F10 siRNA (Human) - CRJ3549 from Cohesion Biosciences
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IL1F10 - MBS8201124 from MyBioSource
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shRNA set against Human IL1F10 (NM_173161.2) - SHH318501 from Creative biogene
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IL1F10 shRNA Plasmid (Human) - CHJ3549 from Cohesion Biosciences
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IL1F10 miRNA 3'UTR clone - MiUTR4H-TG04469 from Creative biogene
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