ATG14

Gene Symbol	ATG14
Entrez Gene	22863
Alt Symbol	ATG14L, BARKOR, KIAA0831
Species	Human
Gene Type	protein-coding
Description	autophagy related 14
Other Description	ATG14 autophagy related 14 homolog|Beclin 1-Interacting protein|autophagy-related protein 14-like protein|beclin 1-associated autophagy-related key regulator
Swissprots	B7ZWP5 Q32MK8 O94920 A8K9U5 Q32MK7 A6NJE4 Q6ZNE5
Accessions	CBX47442 EAW80672 EAW80673 EAW80674 Q6ZNE5 AA988343 AK131251 BAD18430 AK292810 BAF85499 AL049978 BC028015 BC109089 AAI09090 BC109090 AAI09091 BR000826 FAA00433 XM_011536563 XP_011534865 XM_011536564 XP_011534866 NM_014924 NP_055739
Function	Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (By similarity). {ECO:0000250|UniProtKB:Q8CDJ3, ECO:0000269|PubMed:18843052, ECO:0000269|PubMed:19050071, ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:20713597, ECO:0000269|PubMed:23878393}.
Subcellular Location	Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Cytosolic under nutrient-rich conditions. Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes. Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). {ECO:0000250}.
Top Pathways	Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ATG14 Antibody Blocking Peptide - LS-E5789 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ATG14 Antibody Blocking Peptide - LS-E31338 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ATG14-Antibody-N-term-Blocking-peptide - BP1832a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATG14 / Barkor (Center) Control Peptide - AP55472CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

ATG14 Peptide - 7043P from ProSci Category Peptide Species Human

Barkor fusion protein - ag19756 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Barkor fusion protein - Ag19707 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human ATG14 - ATG14-1191H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human KIAA0831, His-tagged - KIAA0831-332H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Beclin 1-associated autophagy-related key regulator(ATG14) - CSB-YP741052HU CSB-EP741052HU CSB-BP741052HU CSB-MP741052HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ATG14 Protein - abx164411 from Abbexa Category Protein Species Human, Mouse, Rat

ATG14-Antibody-Center-Blocking-peptide - BP1832c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATG14 Peptide, Human - M34GP01095H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human Beclin 1-associated autophagy-related key regulator(ATG14) - RPC20400 from Biomatik Category Protein Prices $106.00, $242.00, $380.00, $594.00, $945.00, $1,424.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Recombinant Human Beclin 1-associated autophagy-related key regulator(ATG14) - AP74088 from Signalway Antibody Category Protein Prices $105.00, $260.00, $454.00, $735.00, $1,240.00, $1,980.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Beclin 1-associated autophagy-related key regulator, Recombinant Protein - MBS9423668 from MyBioSource Category Protein Prices $165.00, $280.00, $435.00, $665.00, $1,080.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg Source E Coli Species Human

Beclin 1-associated autophagy-related key regulator (ATG14), Recombinant Protein - MBS1449868 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $950.00, $1,170.00, $1,170.00, $1,180.00, $1,400.00, $1,860.00, $1,860.00, $1,860.00, $2,760.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ATG14 Recombinant Protein (Human) (OPCA04508) - OPCA04508 from Aviva Systems Biology Category Protein Species Human

Human ATG14 protein - orb383315 from Biorbyt Category Protein Species Human

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