| Gene Symbol |
RFWD2
|
| Entrez Gene |
64326
|
| Alt Symbol |
COP1, RNF200
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase RFWD2|RING finger protein 200|constitutive photomorphogenesis protein 1 homolog|putative ubiquitin ligase COP1
|
| Swissprots |
Q6H103 E9PKI0 X5D9B4 Q504W6 Q9H6L7 Q8NHY2
|
| Accessions |
DAA01050 EAW90999 EAW91000 EAW91001 EAW91002 Q8NHY2 AF508940 AAM34692 AF527539 AAQ08989 AK001278 BAG50884 AK314750 BAG37289 AY509921 AAS82851 BC020845 AAH20845 BC039723 BC094728 AAH94728 BG717002 BX537932 CA450176 CD101686 KJ534928 AHW56568 KJ534929 AHW56569 KJ534930 AHW56570 KJ534931 AHW56571 KJ534932 AHW56572 KJ534933 AHW56573 KJ534992 AHW56632 KJ535061 AHW56700 KJ535076 AHW56715 XM_005245447 XP_005245504 XM_005245448 XP_005245505 XM_006711487 XP_006711550 XM_011509881 XP_011508183 XM_011509882 XP_011508184 XM_011509883 XP_011508185 XM_011509884 XP_011508186 XM_011509885 XP_011508187 XM_011509886 XP_011508188 XM_011509887 XP_011508189 XM_011509888 XP_011508190 XM_011509889 XP_011508191 XM_011509890 XP_011508192 NM_001001740 NP_001001740 NM_001286644 NP_001273573 NM_022457 NP_071902
|
| Function |
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal deg
|
| Subcellular Location |
Nucleus speckle. Cytoplasm. Note=In the nucleus, it forms nuclear speckles.
|
| Tissue Specificity |
Ubiquitously expressed at low level. Expressed at higher level in testis, placenta, skeletal muscle and heart. {ECO:0000269|PubMed:12615916, ECO:0000269|PubMed:15103385}.
|
| Top Pathways |
p53 signaling pathway, Ubiquitin mediated proteolysis
|