KLHL2

Gene Symbol	KLHL2
Entrez Gene	11275
Alt Symbol	ABP-KELCH, MAV, MAYVEN
Species	Human
Gene Type	protein-coding
Description	kelch-like family member 2
Other Description	actin-binding protein Mayven|kelch|kelch-like 2, Mayven|kelch-like protein 2
Swissprots	Q8N484 O95198 Q8TBH5 B2RD18 B4DFH7 A6NCM7 F5H6M3
Accessions	EAX04822 EAX04823 EAX04824 EAX04825 O95198 AB209727 BAD92964 AF059569 AAC67502 AI814691 AK025289 AK294103 BAG57438 AK294336 BAG57606 AK308940 AK315372 BAG37765 AL541403 BC022503 AAH22503 BC036468 AAH36468 BX647776 DA250099 DQ893638 ABM84564 DQ895588 ABM86514 XM_005262710 XP_005262767 XM_011531572 XP_011529874 XM_011531573 XP_011529875 XM_011531574 XP_011529876 XM_011531575 XP_011529877 XM_011531576 XP_011529878 XM_011531577 XP_011529879 XR_938681 XR_938682 NM_001161521 NP_001154993 NM_001161522 NP_001154994 NM_007246 NP_009177
Function	Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. {ECO:0000250, ECO:0000269|PubMed:15715669, ECO:0000269|PubMed:23838290}.
Subcellular Location	Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, cytosol. Note=A proportion colocalizes with the actin cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity). {ECO:0000250}.
Tissue Specificity	Ubiquitous. Detected throughout the brain. {ECO:0000269|PubMed:10397770}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

KLHL2/3 (H-253) - sc-99110 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

KLHL9/13 (H-286) - sc-99119 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-KLHL2 antibody - ab198015 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-KLHL2 antibody - ab67525 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-KLHL2 antibody [8D8] - ab117934 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 8D8

Anti-KLHL2 antibody - N-terminal - ab173629 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-KLHL2 / MAV Antibody (clone 8B8) - LS-C115512 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 8B8

Anti-KLHL2 / MAV Antibody (clone 10C12) - LS-C115560 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 10C12

Anti-KLHL2 / MAV Antibody (clone 3H9) - LS-C115514 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3H9

Anti-KLHL2 / MAV Antibody (clone 1G7) - LS-C115559 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1G7

Anti-KLHL2 / MAV Antibody (aa77-103, AP) - LS-C261461 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLHL2 / MAV Antibody (aa77-103, Biotin) - LS-C261463 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLHL2 / MAV Antibody (aa77-103, APC) - LS-C261462 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLHL2 / MAV Antibody (aa77-103, FITC) - LS-C261464 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLHL2 / MAV Antibody (aa77-103, Azide-free, HRP) - LS-C261466 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLHL2 / MAV Antibody (aa77-103, PE) - LS-C261468 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLHL2 / MAV Antibody - LS-C308662 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-KLHL2 / MAV Antibody (aa179-228) - LS-C116480 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-KLHL2 / MAV Antibody (aa1-67) - LS-C308663 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-KLHL2 / MAV Antibody (clone 8D8) - LS-C115561 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 8D8

Anti-KLHL2 / MAV Antibody (aa76-103) - LS-C322518 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLHL2 / MAV Antibody (aa77-103) - LS-C160013 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

KLHL2 Antibody (1G7) - NBP2-02939 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1G7

KLHL2 Antibody - NBP2-17080 from Novus Biologicals Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

KLHL2 Antibody - H00011275-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

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