KLHL2

Gene Symbol KLHL2
Entrez Gene 11275
Alt Symbol ABP-KELCH, MAV, MAYVEN
Species Human
Gene Type protein-coding
Description kelch-like family member 2
Other Description actin-binding protein Mayven|kelch|kelch-like 2, Mayven|kelch-like protein 2
Swissprots Q8N484 O95198 Q8TBH5 B2RD18 B4DFH7 A6NCM7 F5H6M3
Accessions EAX04822 EAX04823 EAX04824 EAX04825 O95198 AB209727 BAD92964 AF059569 AAC67502 AI814691 AK025289 AK294103 BAG57438 AK294336 BAG57606 AK308940 AK315372 BAG37765 AL541403 BC022503 AAH22503 BC036468 AAH36468 BX647776 DA250099 DQ893638 ABM84564 DQ895588 ABM86514 XM_005262710 XP_005262767 XM_011531572 XP_011529874 XM_011531573 XP_011529875 XM_011531574 XP_011529876 XM_011531575 XP_011529877 XM_011531576 XP_011529878 XM_011531577 XP_011529879 XR_938681 XR_938682 NM_001161521 NP_001154993 NM_001161522 NP_001154994 NM_007246 NP_009177
Function Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. {ECO:0000250, ECO:0000269|PubMed:15715669, ECO:0000269|PubMed:23838290}.
Subcellular Location Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, cytosol. Note=A proportion colocalizes with the actin cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitous. Detected throughout the brain. {ECO:0000269|PubMed:10397770}.

Human KLHL2 full length protein - ab161391 from Abcam

Category Protein
Source Wheat germ
Species Human
ab161391 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human KLHL2 protein fragment - ab161392 from Abcam

Category Protein
Source Wheat germ
Species Human
ab161392 on a 12.5% SDS-PAGE stained with Coomassie Blue.

KLHL2 / MAV Antibody Blocking Peptide - LS-E5155 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

KLHL2 / MAV Antibody Blocking Peptide - LS-E18806 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human KLHL2 Protein - H00011275-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human KLHL2 Protein - H00011275-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

KLHL2-Antibody-N-term-Blocking-Peptide - BP17585a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Human KLHL2 protein (GST Tag) - orb139252 from Biorbyt

Category Protein
Prices $323.00, $646.00
Sizes 20 μg, 100 μg
Source E. coli
Species Human
SDS-PAGE analysis of Human KLHL2 protein (GST Tag)

KLHL2 Blocking Peptide - 33R-9385 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

Kelch-like protein 2 - H00011275-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

Kelch-like protein 2 - H00011275-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

Kelch-like protein 2 - H00011275-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

Kelch-like protein 2 - H00011275-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

KLHL2 fusion protein - ag5950 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

KLHL2 fusion protein - ag5289 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human KLHL2, GST tagged - KLHL2-558H from Creative Biomart

Category Protein
Source E. coli
Species Human

Human KLHL2 Protein (GST Tag) - 14556-H09E-100 from Sino Biological

Category Protein
Prices $138.00, $348.00
Sizes 20 µg, 100 µg
Source E. coli
Species Human

Recombinant Human Kelch-like protein 2(KLHL2) - CSB-YP012421HU CSB-EP012421HU CSB-BP012421HU CSB-MP012421HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Kelch-like protein 2 - TP305347 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
Kelch-like protein 2

KLHL2 Protein - NBP2-14165PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 µl
Species Human

KLHL2 Peptide, Human - M34GP08277H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Human KLHL2 Protein (GST Tag) - 14556-H09E from ABclonal

Category Protein
Prices $138.00, $348.00
Sizes 20 µg, 100 µg
Source E. coli
Species Human

Kelch-like protein 2 (KLHL2), Recombinant Protein - MBS1013463 from MyBioSource

Category Protein
Prices $1,395.00, $1,395.00, $1,610.00, $1,610.00, $2,330.00, $2,330.00, $2,770.00, $2,770.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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