| Gene Symbol | KLHL2 |
|---|---|
| Entrez Gene | 11275 |
| Alt Symbol | ABP-KELCH, MAV, MAYVEN |
| Species | Human |
| Gene Type | protein-coding |
| Description | kelch-like family member 2 |
| Other Description | actin-binding protein Mayven|kelch|kelch-like 2, Mayven|kelch-like protein 2 |
| Swissprots | Q8N484 O95198 Q8TBH5 B2RD18 B4DFH7 A6NCM7 F5H6M3 |
| Accessions | EAX04822 EAX04823 EAX04824 EAX04825 O95198 AB209727 BAD92964 AF059569 AAC67502 AI814691 AK025289 AK294103 BAG57438 AK294336 BAG57606 AK308940 AK315372 BAG37765 AL541403 BC022503 AAH22503 BC036468 AAH36468 BX647776 DA250099 DQ893638 ABM84564 DQ895588 ABM86514 XM_005262710 XP_005262767 XM_011531572 XP_011529874 XM_011531573 XP_011529875 XM_011531574 XP_011529876 XM_011531575 XP_011529877 XM_011531576 XP_011529878 XM_011531577 XP_011529879 XR_938681 XR_938682 NM_001161521 NP_001154993 NM_001161522 NP_001154994 NM_007246 NP_009177 |
| Function | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. {ECO:0000250, ECO:0000269|PubMed:15715669, ECO:0000269|PubMed:23838290}. |
| Subcellular Location | Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, cytosol. Note=A proportion colocalizes with the actin cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity). {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. Detected throughout the brain. {ECO:0000269|PubMed:10397770}. |
KLHL2 CRISPR/Cas9 KO Plasmid (h) - sc-405394 from Santa Cruz Biotechnology
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KLHL2 HDR Plasmid (h) - sc-405394-HDR from Santa Cruz Biotechnology
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KLHL2 Double Nickase Plasmid (h) - sc-405394-NIC from Santa Cruz Biotechnology
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KLHL2 Double Nickase Plasmid (h2) - sc-405394-NIC-2 from Santa Cruz Biotechnology
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KLHL2 CRISPR Activation Plasmid (h) - sc-405394-ACT from Santa Cruz Biotechnology
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KLHL2 CRISPR Activation Plasmid (h2) - sc-405394-ACT-2 from Santa Cruz Biotechnology
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KLHL2 Lentiviral Activation Particles (h) - sc-405394-LAC from Santa Cruz Biotechnology
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KLHL2 Lentiviral Activation Particles (h2) - sc-405394-LAC-2 from Santa Cruz Biotechnology
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KLHL2 siRNA (h) - sc-89076 from Santa Cruz Biotechnology
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KLHL2 shRNA Plasmid (h) - sc-89076-SH from Santa Cruz Biotechnology
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KLHL2 shRNA (h) Lentiviral Particles - sc-89076-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU012851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11278 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11278 from Sigma-Aldrich
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KLHL2 siRNA (Human) - CRH7730 from Cohesion Biosciences
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shRNA set against Human KLHL2 (NM_007246.3) - SHH326135 from Creative biogene
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Human KLHL2 siRNA - orb268232 from Biorbyt
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KLHL2 shRNA Plasmid (Human) - CHH7730 from Cohesion Biosciences
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KLHL2 miRNA 3'UTR clone - MiUTR3H-07940 from Creative biogene
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KLHL2 miRNA 3'UTR clone - MiUTR3H-07941 from Creative biogene
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KLHL2 miRNA 3'UTR clone - MiUTR3H-07942 from Creative biogene
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