| Gene Symbol |
AGPAT5
|
| Entrez Gene |
55326
|
| Alt Symbol |
1AGPAT5, LPAATE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
1-acylglycerol-3-phosphate O-acyltransferase 5
|
| Other Description |
1-AGP acyltransferase 5|1-AGPAT 5|1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon|1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)|lysophosphatidic acid acyltransferase epsilon
|
| Swissprots |
Q9NUQ2 Q8IZ47 Q9BQG4
|
| Accessions |
CAH05435 CAH05479 EAW80476 EAW80477 EAW80478 Q9NUQ2 AF375789 AAK54809 AK002072 BAA92069 AK021722 AK310545 AL136587 CAB66522 AL514578 AM392899 CAL37777 AM393058 CAL37936 BC023550 AAH23550 BC068519 AAH68519 BC080537 AAH80537 BM837881 CA414711 DQ893436 ABM84362 DQ896747 ABM87746 XM_011534751 XP_011533053 NM_018361 NP_060831
|
| Function |
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable. {ECO:0000269|PubMed:21173190}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:21173190}; Multi-pass membrane protein {ECO:0000269|PubMed:21173190}. Nucleus envelope {ECO:0000269|PubMed:21173190}. Mitochondrion {ECO:0000269|PubMed:21173190}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:21173190}.
|
| Top Pathways |
Glycerolipid metabolism, Glycerophospholipid metabolism
|
![Western Blot: AGPAT5 Overexpression Lysate (Adult Normal) [NBL1-07386] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AGPAT5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/10147_AGPAT5%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-07386-img0002.jpg)