Gene Symbol | Pdcd1 |
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Entrez Gene | 18566 |
Alt Symbol | Ly101, PD-1, Pdc1 |
Species | Mouse |
Gene Type | protein-coding |
Description | programmed cell death 1 |
Other Description | mPD-1|programmed cell death protein 1|protein PD-1 |
Swissprots | Q02242 |
Accessions | EDL39922 Q02242 AK039828 BAC30463 BC119179 AAI19180 BC120602 AAI20603 X67914 CAA48113 NM_008798 NP_032824 |
Function | Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Thymus. |
Top Pathways | T cell receptor signaling pathway, Cell adhesion molecules (CAMs) |
Pdcd-1 CRISPR/Cas9 KO Plasmid (m) - sc-422150 from Santa Cruz Biotechnology
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Pdcd-1 HDR Plasmid (m) - sc-422150-HDR from Santa Cruz Biotechnology
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Pdcd-1 Double Nickase Plasmid (m) - sc-422150-NIC from Santa Cruz Biotechnology
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Pdcd-1 Double Nickase Plasmid (m2) - sc-422150-NIC-2 from Santa Cruz Biotechnology
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Pdcd-1 CRISPR Activation Plasmid (m) - sc-422150-ACT from Santa Cruz Biotechnology
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Pdcd-1 CRISPR Activation Plasmid (m2) - sc-422150-ACT-2 from Santa Cruz Biotechnology
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Pdcd-1 Lentiviral Activation Particles (m) - sc-422150-LAC from Santa Cruz Biotechnology
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Pdcd-1 Lentiviral Activation Particles (m2) - sc-422150-LAC-2 from Santa Cruz Biotechnology
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Pdcd-1 siRNA (m) - sc-72037 from Santa Cruz Biotechnology
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Pdcd-1 shRNA Plasmid (m) - sc-72037-SH from Santa Cruz Biotechnology
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Pdcd-1 shRNA (m) Lentiviral Particles - sc-72037-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU039251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN38433 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38433 from Sigma-Aldrich
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PDCD1 siRNA (Mouse) - CRM2985 from Cohesion Biosciences
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shRNA set against Mouse PDCD1 (NM_008798.2) - SHH372144 from Creative biogene
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Mouse PD1 siRNA - orb282461 from Biorbyt
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PDCD1 shRNA Plasmid (Mouse) - CHM2985 from Cohesion Biosciences
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