| Gene Symbol | CYP7A1 |
|---|---|
| Entrez Gene | 1581 |
| Alt Symbol | CP7A, CYP7, CYPVII |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytochrome P450, family 7, subfamily A, polypeptide 1 |
| Other Description | cholesterol 7-alpha-hydroxylase|cholesterol 7-alpha-monooxygenase|cytochrome P450 7A1|cytochrome P450, subfamily VIIA polypeptide 1 |
| Swissprots | Q7KZ19 P22680 P78454 Q3MIL8 |
| Accessions | AAA58423 AAA61350 EAW86811 P22680 BC101777 AAI01778 BC112184 AAI12185 M93133 AAA58435 X56088 CAA39568 XM_011517476 XP_011515778 NM_000780 NP_000771 |
| Function | Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. {ECO:0000269|PubMed:19965590}. |
| Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Tissue Specificity | Detected in liver. {ECO:0000269|PubMed:15796896}. |
| Top Pathways | Primary bile acid biosynthesis, Steroid hormone biosynthesis, PPAR signaling pathway, Bile secretion |