Gene Symbol | CYP7A1 |
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Entrez Gene | 1581 |
Alt Symbol | CP7A, CYP7, CYPVII |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 7, subfamily A, polypeptide 1 |
Other Description | cholesterol 7-alpha-hydroxylase|cholesterol 7-alpha-monooxygenase|cytochrome P450 7A1|cytochrome P450, subfamily VIIA polypeptide 1 |
Swissprots | Q7KZ19 P22680 P78454 Q3MIL8 |
Accessions | AAA58423 AAA61350 EAW86811 P22680 BC101777 AAI01778 BC112184 AAI12185 M93133 AAA58435 X56088 CAA39568 XM_011517476 XP_011515778 NM_000780 NP_000771 |
Function | Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. {ECO:0000269|PubMed:19965590}. |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Tissue Specificity | Detected in liver. {ECO:0000269|PubMed:15796896}. |
Top Pathways | Primary bile acid biosynthesis, Steroid hormone biosynthesis, PPAR signaling pathway, Bile secretion |
Human CYP7A1 peptide - ab69726 from Abcam
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CYP7A1 Antibody Blocking Peptide - LS-E9411 from LifeSpan Bioscience
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CYP7A1-Antibody-N-term-Blocking-Peptide - BP7996b from Abgent, a WuXi AppTec company
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CYP7A1-Antibody-C-term-Blocking-Peptide - BP7996a from Abgent, a WuXi AppTec company
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CYP7A1 - H00001581-Q01-10 from Acris Antibodies
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CYP7A1 - H00001581-Q01-25 from Acris Antibodies
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CYP7A1 fusion protein - ag12572 from Proteintech Group
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CYP7A1 fusion protein - Ag12681 from Proteintech Group
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Recombinant Cytochrome P450 7A1 (CYP7A1) - RPB053Hu01 from Uscn Life Science Inc.
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Recombinant Cytochrome P450 7A1 (CYP7A1) - RPB053Mu01 from Uscn Life Science Inc.
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Recombinant Cytochrome P450 7A1 (CYP7A1) - RPB053Mu02 from Uscn Life Science Inc.
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Recombinant Cytochrome P450 7A1 (CYP7A1) - RPB053Ra01 from Uscn Life Science Inc.
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Recombinant Cytochrome P450 7A1 (CYP7A1) - RPB053Hu01 from Cloud-clone
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Recombinant Human Cholesterol 7-alpha-monooxygenase(CYP7A1) - CSB-YP006460HU CSB-EP006460HU CSB-BP006460HU CSB-MP006460HU from Cusabio
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CYP7A1 - TP311019 from Acris Antibodies
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CYP7A1-Blocking-Peptide-N-term - BP21523a from Abgent, a WuXi AppTec company
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CYP7A1 Peptide, Human - M34GP03988H from Creative Peptides
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Cholesterol 7-alpha-monooxygenase (CYP7A1), Recombinant Protein - MBS960575 from MyBioSource
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CYP7A1 fusion protein - Ag26621 from Proteintech Group
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