| Gene Symbol |
CYP2A6
|
| Entrez Gene |
1548
|
| Alt Symbol |
CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 2, subfamily A, polypeptide 6
|
| Other Description |
1,4-cineole 2-exo-monooxygenase|coumarin 7-hydroxylase|cytochrome P450 2A6|cytochrome P450 IIA3|cytochrome P450(I)|cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6|flavoprotein-linked monooxygenase|xenobiotic monooxygenase
|
| Swissprots |
Q9H1Z7 Q16803 A7YAE5 Q4VAU0 Q4VAT9 Q9UK48 Q4VAU1 P10890 Q9UCU0 B2R7F6 P00190 P11509
|
| Accessions |
AAB40518 AAG45229 ABV02584 ACK44068 EAW57012 P11509 AF182275 AAF13600 AK307740 AK309594 AK312964 BAG35803 BC096253 AAH96253 BC096254 AAH96254 BC096255 AAH96255 BC096256 AAH96256 DA641580 HQ258268 ADR83022 M33318 AAA52067 X06401 X13897 CAA32097 X13929 CAA32117 X13930 CAA32118 NM_000762 NP_000753
|
| Function |
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4- cineole 2-exo-monooxygenase. Possesses low phenacetin O- deethylation activity. {ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:16086027, ECO:0000269|PubMed:17125252, ECO:0000269|PubMed:18779312, ECO:0000269|PubMed:1889415, ECO:0000269|PubMed:1944238}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
|
| Tissue Specificity |
Liver. {ECO:0000269|PubMed:1889415, ECO:0000269|PubMed:1944238}.
|
| Top Pathways |
Chemical carcinogenesis, Caffeine metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450
|