MCAM

Gene Symbol	MCAM
Entrez Gene	4162
Alt Symbol	CD146, MUC18
Species	Human
Gene Type	protein-coding
Description	melanoma cell adhesion molecule
Other Description	Gicerin|S-endo 1 endothelial-associated antigen|cell surface glycoprotein MUC18|cell surface glycoprotein P1H12|melanoma adhesion molecule|melanoma-associated antigen A32|melanoma-associated antigen MUC18
Swissprots	Q6PHR3 Q59E86 Q6ZTR2 O95812 P43121
Accessions	CAA48332 CCF76943 EAW67477 EAW67478 P43121 AB209925 BAD93162 AF089868 AAD17799 AJ297452 CAB97348 AK126303 BAC86520 AK128335 BAG54661 AK291571 BAF84260 AK312430 BAG35339 AU076908 BC056418 AAH56418 EU832794 ACE87805 GQ129330 ACT64464 M28882 AAA20922 M29277 AAA20824 NM_006500 NP_006491
Function	Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MCAM / CD146 ELISA Kit (Sandwich ELISA) - LS-F4898 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.67 ng/ml Range 1.56-100 ng/ml

Mouse MCAM / CD146 ELISA Kit (Sandwich ELISA) - LS-F7609 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.251 ng/ml Range 1.56-100 ng/ml

Human MCAM / CD146 ELISA Kit (Sandwich ELISA) - LS-F12100 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.625 Range 1.56-100 ng/ml

Human MCAM ELISA Kit - abx152285 from Abbexa Category ELISA Kit Sensitivity 1.21 ng/ml Range 3.125 ng/ml - 200 ng/ml

Cell surface glycoprotein MUC18, MCAM, Human, ELISA Kit - E1670h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.625-40 ng/mL

Melanoma Cell Adhesion Molecule, MCAM, Human, ELISA Kit - E-EL-H2403 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.375 Range 0.625-40ng/mL

Melanoma Cell Adhesion Molecule (MCAM), Human, ELISA Kit - SEB670Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 1.44ng/mL Range 3.12-200ng/mL

Melanoma Cell Adhesion Molecule, MCAM, Rabbit, ELISA Kit - E-EL-RB1705 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Melanoma Cell Adhesion Molecule, MCAM, Chicken, ELISA Kit - E-EL-Ch0681 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Melanoma Cell Adhesion Molecule, MCAM, Porcine, ELISA Kit - E-EL-P0505 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Melanoma Cell Adhesion Molecule, MCAM, Guinea Pig, ELISA Kit - E-EL-GP0148 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Melanoma Cell Adhesion Molecule, MCAM, Monkey, ELISA Kit - E-EL-MK0498 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

MCAM - KE00065 from Acris Antibodies Category ELISA Kit Prices $599.00 Sizes 1 kit Range 0.2 ng/ml

Human MCAM ELISA Kit - KE00065 from Proteintech Group Category ELISA Kit Prices $599.00 Sizes 1 Sensitivity 0.03 ng/mL Range 0.2 ng/mL - 16 ng/mL

Melanoma Cell Adhesion Molecule, ELISA Kit - MBS102951 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Melanoma Cell Adhesion Molecule, ELISA Kit - MBS080180 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Melanoma Cell Adhesion Molecule, ELISA Kit - MBS048196 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Melanoma Cell Adhesion Molecule, ELISA Kit - MBS053651 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Melanoma Cell Adhesion Molecule, ELISA Kit - MBS092826 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human MCAM(Melanoma Cell Adhesion Molecule) ELISA Kit - E-EL-H2403 from Elabscience Category ELISA Kit Sensitivity 0.38 ng/mL Range 0.63—40 ng/mL

Human MCAM (Melanoma Cell Adhesion Molecule) CLIA Kit - E-CL-H1408 from Elabscience Category CLIA Kit Sensitivity 75.00 pg/mL Range Average Recovery (%)

Melanoma Cell Adhesion Molecule, ELISA Kit - MBS055740 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Melanoma Cell Adhesion Molecule, ELISA Kit - MBS085472 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Melanoma Cell Adhesion Molecule (MCAM), ELISA Kit - MBS2019700 from MyBioSource Category ELISA Kit Prices $355.00, $540.00, $730.00, $2,985.00, $5,410.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.67ng/mL. Range 1.56-100ng/mL

Melanoma Cell Adhesion Molecule (MCAM), ELISA Kit - MBS2020029 from MyBioSource Category ELISA Kit Prices $370.00, $550.00, $750.00, $3,065.00, $5,550.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.251ng/mL. Range 0.625-40ng/mL

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