MCAM

Gene Symbol	MCAM
Entrez Gene	4162
Alt Symbol	CD146, MUC18
Species	Human
Gene Type	protein-coding
Description	melanoma cell adhesion molecule
Other Description	Gicerin|S-endo 1 endothelial-associated antigen|cell surface glycoprotein MUC18|cell surface glycoprotein P1H12|melanoma adhesion molecule|melanoma-associated antigen A32|melanoma-associated antigen MUC18
Swissprots	Q6PHR3 Q59E86 Q6ZTR2 O95812 P43121
Accessions	CAA48332 CCF76943 EAW67477 EAW67478 P43121 AB209925 BAD93162 AF089868 AAD17799 AJ297452 CAB97348 AK126303 BAC86520 AK128335 BAG54661 AK291571 BAF84260 AK312430 BAG35339 AU076908 BC056418 AAH56418 EU832794 ACE87805 GQ129330 ACT64464 M28882 AAA20922 M29277 AAA20824 NM_006500 NP_006491
Function	Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD146 full length protein - ab114180 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human CD146 peptide - ab101311 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human CD146 protein fragment - ab155626 from Abcam Category Protein Prices $456.00 Sizes 100 µg Source HEK 293 cells Species Human

Human CD146 protein fragment - ab174021 from Abcam Category Protein Prices $365.00 Sizes 100 µg Source HEK 293 cells Species Human

MCAM / CD146 Antibody Blocking Peptide - LS-E7082 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MCAM / CD146 Antibody Blocking Peptide - LS-E7083 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MCAM / CD146 Antibody Blocking Peptide - LS-E23152 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MCAM / CD146 Antibody Blocking Peptide - LS-E23153 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MCAM/CD146 Recombinant Protein - H00004162-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

MCAM-Antibody-Center-Blocking-Peptide - BP2767C from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MCAM-Antibody-C-term-Blocking-Peptide - BP2767b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MCAM-Antibody-Y641-Blocking-Peptide - BP2767a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human CRISP1 protein - orb81001 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human CD146 protein - orb176023 from Biorbyt Category Protein Prices $366.00, $476.00 Sizes 2 μl, 5 μl

Human MCAM protein - orb245462 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human MCAM Protein - abx067983 from Abbexa Category Protein Source E.coli Species Human

CD146 - H00004162-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD146 - H00004162-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

CD146 - H00004162-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

CD146 - H00004162-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

Melanoma Cell Adhesion Molecule (MCAM), Human - 20-7913 from ARP American Research Products Category Protein Prices $429.00 Sizes 50 µg Source E.coli Species Human

MCAM Recombinant Protein - 96-126 from ProSci Category Protein Prices $375.00 Sizes 100 µg Source HEK293 cells Species Human

MCAM Recombinant Protein - 96-125 from ProSci Category Protein Prices $500.00 Sizes 100 µg Source HEK293 cells Species Human

CD146, MCAM fusion protein - Ag11762 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

CD146, MCAM fusion protein - Ag11855 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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