ACO1

Gene Symbol ACO1
Entrez Gene 48
Alt Symbol ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1
Species Human
Gene Type protein-coding
Description aconitase 1, soluble
Other Description IRE-BP 1|aconitate hydratase, cytoplasmic|citrate hydro-lyase|cytoplasmic aconitate hydratase|epididymis luminal protein 60|ferritin repressor protein|iron regulatory protein 1|iron-responsive element binding protein 1|iron-responsive element-binding protein 1
Swissprots P21399 Q14652 D3DRK7 Q5VZA7
Accessions ABF47095 EAW58549 EAW58550 EAW58551 EAW58552 P21399 AB209480 BAD92717 AF261088 AAF99681 AK057904 AK308752 BC018103 AAH18103 BP287929 BX538349 CAD98144 DA103947 DA409113 DA780353 EU794627 ACJ13681 M58510 AAA69900 Z11559 CAA77651 XM_005251476 XP_005251533 XM_011517888 XP_011516190 NM_001278352 NP_001265281 NM_002197 NP_002188
Function Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. {ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:8041788}.
Subcellular Location Cytoplasm.
Top Pathways Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism, Carbon metabolism

IRP-1 (E-12) - sc-166022 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IRP-1 (E-12): sc-166022. Western blot analysis of IRP-1 expression in non-transfected: sc-110760 (A) and human IRP-1 transfected: sc-113248 (B) 293T whole cell lysates.

IRP-1 (N-17) - sc-14216 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IRP-1 (N-17) : sc-14216. Western blot analysis of IRP-1 expression in HeLa whole cell lysate.

IRP-1 (H-64) - sc-25535 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IRP-1 (H-64): sc-25535. Western blot analysis of IRP-1 expression in non-transfected: sc-117752 (A) and mouse IRP-1 transfected: sc-125502 (B) 293T whole cell lysates.

Anti-Aconitase 1 (phospho S138) antibody - ab63260 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Aconitase 1 (phospho S138) expression in paraffin-embedded human ovary tissue using ab63260 at 1/50. Left image: untreated. Right image: sample treated with immunising phosphopeptide.

Anti-Aconitase 1 (phospho S711) antibody - ab62451 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62451, at 1/50 dilution, staining Aconitase 1 in paraffin embedded human thyroid gland tissue by Immunohistochemistry in the absence or presence of the immunising peptide.

Anti-Aconitase 1 antibody - ab88313 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Aconitase 1 antibody (ab88313) at 1 µg/mlLane 1 : Aconitase 1 transfected 293T cell lysateLane 2 : untransfected 293T cell lysateLysates/proteins at 50 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-Aconitase 1 antibody - ab151242 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-Aconitase 1 antibody - ab61197 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab61197 at 1/500 dilution staining Aconitase 1 in HeLa cells by Immunofluorescence, in the absence (left) or presence (right) of the immunising peptide.

Anti-Aconitase 1 antibody - ab62701 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62701, at 1/50 dilution, staining Aconitase 1 in paraffin embedded human thyroid gland tissue by Immunohistochemistry in the absence or presence of the immunising peptide.

Anti-Aconitase 1 antibody - ab102803 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Aconitase 1 antibody (ab102803) at 1/500 dilution + Human liver tissue lysate at 50 µg

Anti-Aconitase 1 antibody - ab54718 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab54718 Aconitase 1 antibody at 1ug/ml.

Anti-Aconitase 1 antibody [EPR7225] - ab126595 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7225
All lanes : Anti-Aconitase 1 antibody [EPR7225] (ab126595) at 1/1500 dilution (purified)Lane 1 : kidneyLane 2 : kidneySecondaryHRP goat anti-rabbit (H+L) at 1/1000 dilution

Anti-Aconitase 1 antibody [EPR7225] (Alexa Fluor® 488) - ab200756 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7225
ab200756 staining Aconitase 1 in HeLa cells. The cells were fixed with 4% formaldehyde (10min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab200756 at 1/100 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at 2µg/ml (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-Aconitase 1 antibody [EPR7225] (Alexa Fluor® 647) - ab200761 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7225
ab200761 staining Aconitase 1 in HeLa cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab200761 at 1/200 dilution (shown in red) and ab195887, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 488), at 2µg/ml (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-Aconitase 1 antibody [EPR7226(2)] - ab183721 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7226(2)
Anti-Aconitase 1 antibody [EPR7226(2)] (ab183721) at 1/20000 dilution + Human fetal liver tissue lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-ACO1 / Aconitase Antibody (aa30-44) - LS-C112852 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ACO1 antibody (0.1 ug/ml) staining of Human Liver lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-ACO1 / Aconitase Antibody (aa106-155) - LS-C117970 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human colon carcinoma tissue, using IREB1 (Ab-138) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-ACO1 / Aconitase Antibody (phospho-Ser138) - LS-C199135 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human ovary, using IREB1 (Phospho-Ser138) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-ACO1 / Aconitase Antibody (Arg134) - LS-C176537 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of IRP-1 (R134) pAb in paraffin-embedded human colon carcinoma tissue.

Anti-ACO1 / Aconitase Antibody (Asn707) - LS-C176609 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of IRP-1 (N707) pAb in paraffin-embedded human cervix carcinoma tissue.

Anti-ACO1 / Aconitase Antibody (phospho-Ser711) - LS-C199136 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human thyroid gland, using IREB1 (Phospho-Ser711) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-IRP1 / Aconitase Antibody (Internal, clone EPR7225) - LS-C152312 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7225
Immunofluorescent staining of HeLa cells using anti-ACO1 antibody.

Anti-ACO1 / Aconitase Antibody (clone 2C1) - LS-C196600 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C1
Immunoprecipitation of ACO1 transfected lysate using anti-ACO1 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with ACO1 rabbit polyclonal antibody.

Anti-ACO1 / Aconitase Antibody (aa26-243, Biotin) - LS-C298068 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ACO1 / Aconitase Antibody (aa458-586, Biotin) - LS-C301329 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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