ACO1

Gene Symbol	ACO1
Entrez Gene	48
Alt Symbol	ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1
Species	Human
Gene Type	protein-coding
Description	aconitase 1, soluble
Other Description	IRE-BP 1|aconitate hydratase, cytoplasmic|citrate hydro-lyase|cytoplasmic aconitate hydratase|epididymis luminal protein 60|ferritin repressor protein|iron regulatory protein 1|iron-responsive element binding protein 1|iron-responsive element-binding protein 1
Swissprots	P21399 Q14652 D3DRK7 Q5VZA7
Accessions	ABF47095 EAW58549 EAW58550 EAW58551 EAW58552 P21399 AB209480 BAD92717 AF261088 AAF99681 AK057904 AK308752 BC018103 AAH18103 BP287929 BX538349 CAD98144 DA103947 DA409113 DA780353 EU794627 ACJ13681 M58510 AAA69900 Z11559 CAA77651 XM_005251476 XP_005251533 XM_011517888 XP_011516190 NM_001278352 NP_001265281 NM_002197 NP_002188
Function	Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. {ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:8041788}.
Subcellular Location	Cytoplasm.
Top Pathways	Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism, Carbon metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ACO1 / Aconitase ELISA Kit (Sandwich ELISA) - LS-F6796 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.277 ng/ml Range 0.625-40 ng/ml

Rat ACO1 / Aconitase ELISA Kit (Sandwich ELISA) - LS-F8597 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.116 ng/ml Range 0.625-40 ng/ml

Aconitase 1 Colorimetric Assay Kit - KA0876 from Novus Biologicals Category Assay Kit Prices $599.00 Sizes 1 kit

Aconitase 1, ACO1, Human, ELISA Kit - E-EL-H0350 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Aconitase 1 (ACO1), Human, ELISA Kit - SEJ683Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.115ng/mL Range 0.312-20ng/mL

Cytoplasmic aconitate hydase (ACO1), Human, ELISA Kit - E01C1180 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Cytoplasmic aconitate hydratase (ACO1), Human, ELISA Kit - CSB-EL001161HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Aconitase 1, ACO1, Rabbit, ELISA Kit - E-EL-RB0306 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Aconitase 1, ACO1, Chicken, ELISA Kit - E-EL-Ch0893 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Aconitase 1, ACO1, Porcine, ELISA Kit - E-EL-P1983 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Aconitase 1, ACO1, Monkey, ELISA Kit - E-EL-MK0068 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

ACO1 (Human) IP-WB Antibody Pair - H00000048-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

ACO1 (Human) IP-WB Antibody Pair - H00000048-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

ACO1 (Human) Matched Antibody Pair - H00000048-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human ACO1(Aconitase 1) ELISA Kit - E-EL-H0350 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human ACO1 (Aconitase 1) CLIA Kit - E-CL-H0282 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

aconitase 1, soluble, ELISA Kit - MBS947806 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human ACO1 is typically less than 15.6 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 62.5 pg/ml-4000 pg/ml.

ELISA Kit for Aconitase 1 (ACO1) - SEJ683Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.277ng/mL. Range 0.625-40ng/mL The standard curve concentrations used for the ELISA’s were 40ng/mL, 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL

ELISA Kit for Aconitase 1 (ACO1) - SEJ683Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.116ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human Cytoplasmic aconitate hydratase(ACO1) ELISA kit - CSB-EL001161HU from Cusabio Category ELISA Kit Sensitivity Request Information Range Request Information

ELISA Kit for Aconitase 1 (ACO1) - SEJ683Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.277ng/mL. Range 0.625-40ng/mL The standard curve concentrations used for the ELISA's were 40ng/mL, 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL

Human ACO1(Aconitase 1) ELISA Kit - E-EL-H0350 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mLng/mL Range 0.16~10 ng/mL

Human ALD (Aldosterone) CLIA Kit - E-CL-H0248 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 18.75pg/mL Range 31.25-2000pg/mL

Human ACO1 / Aconitase ELISA Kit (Sandwich ELISA) - LS-F20897 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.094 ng/ml Range 0.625-40 ng/ml

Aconitase 1 (ACO1), Human, ELISA Kit - DL-ACO1-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

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