ACO1

Gene Symbol	ACO1
Entrez Gene	48
Alt Symbol	ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1
Species	Human
Gene Type	protein-coding
Description	aconitase 1, soluble
Other Description	IRE-BP 1|aconitate hydratase, cytoplasmic|citrate hydro-lyase|cytoplasmic aconitate hydratase|epididymis luminal protein 60|ferritin repressor protein|iron regulatory protein 1|iron-responsive element binding protein 1|iron-responsive element-binding protein 1
Swissprots	P21399 Q14652 D3DRK7 Q5VZA7
Accessions	ABF47095 EAW58549 EAW58550 EAW58551 EAW58552 P21399 AB209480 BAD92717 AF261088 AAF99681 AK057904 AK308752 BC018103 AAH18103 BP287929 BX538349 CAD98144 DA103947 DA409113 DA780353 EU794627 ACJ13681 M58510 AAA69900 Z11559 CAA77651 XM_005251476 XP_005251533 XM_011517888 XP_011516190 NM_001278352 NP_001265281 NM_002197 NP_002188
Function	Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. {ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:8041788}.
Subcellular Location	Cytoplasm.
Top Pathways	Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism, Carbon metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Aconitase 1 full length protein - ab103501 from Abcam Category Protein Prices $235.00, $866.00 Sizes 10 µg, 50 µg Source E. coli Species Human

ACO1 / Aconitase Antibody Blocking Peptide - LS-E27112 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Aconitase 1 Recombinant Protein - H00000048-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Aconitase 1 Partial Recombinant Protein - H00000048-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Aconitase 1 Protein - NBP1-50955 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 10 µg, 50 µg Source E. coli Species Human

ACO1 Protein (OPPA02497) - OPPA02497 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 1 µg Source E. Coli

Human ACO1 protein - orb167840 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 1 μg, 5 μg, 50 μg Source E. coli

Human ACO1 protein (His Tag) - orb138119 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Baculovirus-Insect Cells Species Human

ACO1 Blocking Peptide - 33R-6475 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ACO1 protein (His tag) - 80R-1630 from Fitzgerald Category Protein Prices $255.00 Sizes 10 µg Source E.coli

Human Aconitase 1 Protein - abx065103 from Abbexa Category Protein Source E.coli Species Human

Human Aconitase 1 Protein - abx065100 from Abbexa Category Protein Source E.coli Species Human

Human Aconitase 1 Protein - abx065102 from Abbexa Category Protein Source E.coli Species Human

Human Aconitase 1 Protein - abx065101 from Abbexa Category Protein Source E.coli Species Human

Aconitase 1 Peptide - AC21-1932-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ACO1 / IREB1 (1-889, His-tag) - AR09811PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

ACO1 / IREB1 (1-889, His-tag) - AR09811PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

ACO1 / IREB1 - H00000048-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

ACO1 / IREB1 - H00000048-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ACO1 / IREB1 - H00000048-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ACO1 / IREB1 - H00000048-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ACO1 / IREB1 - H00000048-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Aconitase-1, Human Recombinant - 228-12208-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

ACO1, 1-889aa, Human, His tag, E.coli - 01-P0871 from ARP American Research Products Category Protein Prices $159.00, $369.00, $849.00 Sizes 2 µg, 10 µg, 50 µg Species Human

Aconitase 1 (ACO1), Human - 20-9389 from ARP American Research Products Category Protein Prices $669.00 Sizes 50 µg Source E.coli Species Human

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