| Gene Symbol | ACO1 |
|---|---|
| Entrez Gene | 48 |
| Alt Symbol | ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | aconitase 1, soluble |
| Other Description | IRE-BP 1|aconitate hydratase, cytoplasmic|citrate hydro-lyase|cytoplasmic aconitate hydratase|epididymis luminal protein 60|ferritin repressor protein|iron regulatory protein 1|iron-responsive element binding protein 1|iron-responsive element-binding protein 1 |
| Swissprots | P21399 Q14652 D3DRK7 Q5VZA7 |
| Accessions | ABF47095 EAW58549 EAW58550 EAW58551 EAW58552 P21399 AB209480 BAD92717 AF261088 AAF99681 AK057904 AK308752 BC018103 AAH18103 BP287929 BX538349 CAD98144 DA103947 DA409113 DA780353 EU794627 ACJ13681 M58510 AAA69900 Z11559 CAA77651 XM_005251476 XP_005251533 XM_011517888 XP_011516190 NM_001278352 NP_001265281 NM_002197 NP_002188 |
| Function | Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. {ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:8041788}. |
| Subcellular Location | Cytoplasm. |
| Top Pathways | Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism, Carbon metabolism |