PDGFRB
| Gene Symbol | PDGFRB |
|---|---|
| Entrez Gene | 5159 |
| Alt Symbol | CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR-1, PDGFR1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | platelet-derived growth factor receptor, beta polypeptide |
| Other Description | CD140 antigen-like family member B|PDGF-R-beta|PDGFR-beta|beta-type platelet-derived growth factor receptor|platelet-derived growth factor receptor 1|platelet-derived growth factor receptor beta |
| Swissprots | B5A957 P09619 Q8N5L4 |
| Accessions | AAA52119 AAC51675 EAW61746 EAW61747 EAW61748 P09619 AB209657 BAD92894 AI346188 AK293093 BAF85782 BC032224 AAH32224 CN268096 DQ892124 ABM83050 EU176549 ABW03350 EU826595 ACF47631 J03278 AAA60049 M21616 AAA36427 M30493 XM_005268464 XP_005268521 XM_011537658 XP_011535960 XM_011537659 XP_011535961 XM_011537660 XP_011535962 NM_002609 NP_002600 |
| Function | Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGF |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation. |
| Top Pathways | Rap1 signaling pathway, MicroRNAs in cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, Cytokine-cytokine receptor interaction |
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