PDGFRB

Gene Symbol	PDGFRB
Entrez Gene	5159
Alt Symbol	CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR-1, PDGFR1
Species	Human
Gene Type	protein-coding
Description	platelet-derived growth factor receptor, beta polypeptide
Other Description	CD140 antigen-like family member B|PDGF-R-beta|PDGFR-beta|beta-type platelet-derived growth factor receptor|platelet-derived growth factor receptor 1|platelet-derived growth factor receptor beta
Swissprots	B5A957 P09619 Q8N5L4
Accessions	AAA52119 AAC51675 EAW61746 EAW61747 EAW61748 P09619 AB209657 BAD92894 AI346188 AK293093 BAF85782 BC032224 AAH32224 CN268096 DQ892124 ABM83050 EU176549 ABW03350 EU826595 ACF47631 J03278 AAA60049 M21616 AAA36427 M30493 XM_005268464 XP_005268521 XM_011537658 XP_011535960 XM_011537659 XP_011535961 XM_011537660 XP_011535962 NM_002609 NP_002600
Function	Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGF
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
Top Pathways	Rap1 signaling pathway, MicroRNAs in cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PDGF Receptor beta protein fragment - ab155703 from Abcam Category Protein Prices $352.00 Sizes 100 µg Source HEK 293 cells Species Human

Active PDGF Receptor beta protein fragment - ab60833 from Abcam Category Protein Prices $294.00, $1,845.00 Sizes 10 µg, 100 µg Source Insect cells

Human PDGF Receptor beta protein fragment - ab159082 from Abcam Category Protein Source Wheat germ Species Human

Human PDGF Receptor beta protein fragment - ab151850 from Abcam Category Protein Source HEK 293 cells Species Human

Human PDGF Receptor beta protein fragment - ab185609 from Abcam Category Protein Source E. coli Species Human

PDGFRB / PDGFR Beta Antibody Blocking Peptide - LS-E9171 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDGFRB / PDGFR Beta Antibody Blocking Peptide - LS-E29639 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PDGFRB / PDGFR Beta Antibody Blocking Peptide - LS-E29640 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human PDGF R beta Protein - H00005159-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PDGF R beta Recombinant Protein - P4248 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

PDGF R beta Recombinant Protein - P4749 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant PDGF R beta Protein - NBP1-99504 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

Recombinant Human PDGF R beta Protein - H00005159-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

PDGF R beta Peptide - P2713 from Novus Biologicals Category Peptide Species Human

PDGF R beta Peptide - P2712 from Novus Biologicals Category Peptide Species Human

PDGFRB-Antibody-N-term-Blocking-Peptide - BP7667a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDGF Receptor beta (Active) recombinant protein - GTX65198 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Recombinant Human PDGF R beta Fc Chimera - 385-PR-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human PDGF R beta Fc Chimera, CF - 385-PR-100/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human PDGFRB Fc His tag protein - orb84323 from Biorbyt Category Protein Prices $570.00, $748.00 Sizes 100 μg, 200 μg Source Human Species Human

Human PDGFRB protein - orb139462 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source Human Cells Species Human

Human PDGFR beta protein - orb49592 from Biorbyt Category Protein Prices $213.00, $408.00, $1,411.00, $1,981.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source HEK293

Cynomolgus PDGFRB protein (His Tag) - orb139463 from Biorbyt Category Protein Prices $434.00, $612.00 Sizes 100 μg, 200 μg Source Human Cells

Human PDGFRB His tag protein - orb83427 from Biorbyt Category Protein Prices $298.00, $400.00 Sizes 50 μg, 100 μg Source Human Species Human

CD140b / PDGFRB - H00005159-G01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

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