PDGFRB

Gene Symbol PDGFRB
Entrez Gene 5159
Alt Symbol CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR-1, PDGFR1
Species Human
Gene Type protein-coding
Description platelet-derived growth factor receptor, beta polypeptide
Other Description CD140 antigen-like family member B|PDGF-R-beta|PDGFR-beta|beta-type platelet-derived growth factor receptor|platelet-derived growth factor receptor 1|platelet-derived growth factor receptor beta
Swissprots B5A957 P09619 Q8N5L4
Accessions AAA52119 AAC51675 EAW61746 EAW61747 EAW61748 P09619 AB209657 BAD92894 AI346188 AK293093 BAF85782 BC032224 AAH32224 CN268096 DQ892124 ABM83050 EU176549 ABW03350 EU826595 ACF47631 J03278 AAA60049 M21616 AAA36427 M30493 XM_005268464 XP_005268521 XM_011537658 XP_011535960 XM_011537659 XP_011535961 XM_011537660 XP_011535962 NM_002609 NP_002600
Function Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGF
Subcellular Location Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
Top Pathways Rap1 signaling pathway, MicroRNAs in cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, Cytokine-cytokine receptor interaction

PDGF Receptor β (28E1) Rabbit mAb (Biotinylated) - 8044 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 28E1
Western blot analysis of extracts from NIH/3T3 and NCI-H1703 cells using PDGF Receptor β (28E1) Rabbit mAb (Biotinylated).

Phospho-PDGF Receptor β (Tyr1009) (42F9) Rabbit mAb - 3124 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 42F9
Western blot analysis of cell extracts from NIH/3T3 cells unstimulated or stimulated with PDGF-BB (100 ng/ml for 5 min), using Phospho-PDGF Receptor-β (Tyr1009) (42F9) Rabbit mAb (upper) or PDGF receptor-β (2B3) Mouse mAb #3175 (lower).

Phospho-PDGF Receptor β (Tyr751) Antibody - 3161 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines, untreated or PDGF-stimulated (40 ng/ml for 5 minutes), using Phospho-PDGF Receptor β (Tyr751) Antibody.

Phospho-PDGF Receptor β (Tyr751) (88H8) Mouse mAb - 3166 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 88H8
Western blot analysis of extracts from NIH/3T3 cells, untreated or treated with PDGF (50 ng/ml for 5 minutes) and/or calf intestinal phosphatase (CIP) as indicated, using Phospho-PDGF Receptor β (Tyr751) (88H8) Mouse mAb.

Phospho-PDGF Receptor β (Tyr771) (76D6) Rabbit mAb - 3173 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 76D6
Western blot analysis of extracts from NIH/3T3 cells untreated or treated with PDGF-BB, using Phospho-PDGF Receptor beta (Tyr771) (76D6) Rabbit mAb (upper) or PDGF Receptor beta (28E1) Rabbit mAb #3169.

Phospho-PDGF Receptor β (Tyr1021) (6F10) Rabbit mAb - 2227 from Cell Signaling Technology

Prices $109.00, $287.00, $678.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Monoclonal
Clone 6F10
Western blot analysis of extracts of NIH/3T3 cells untreated or treated with PDGF-BB, using Phospho-PDGF Receptor β (Tyr1021) (6F10) Rabbit mAb (upper), or PDGF Receptor β (2B3) Mouse mAb (#3175) (lower).

Phospho-PDGF Receptor β (Tyr751) (C63G6) Rabbit mAb - 4549 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C63G6
Western blot analysis of extracts of NIH/3T3 cells, untreated or stimulated with Platelet-Derived Growth Factor (PDGF) #9909, using Phospho-PDGF Receptor-β (Tyr751) (C63G6) Rabbit mAb (upper) or PDGF Receptor-β (2B3) Mouse mAb #3175 (lower).

Phospho-PDGF Receptor β (Tyr740) (32A9) Rabbit mAb - 3168 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 32A9
Phospho-PDGF Receptor β (Tyr740) (32A9) Rabbit mAb specifically binds to tyrosine phosphorylated PDGF receptor-β, but not other phosphorylated tyrosine kinases. Western blot analysis of extracts from cells expressing different activated tyrosine kinase proteins, using Phospho-PDGF Receptor beta (Tyr740) (32A9) Rabbit mAb (upper) or Phospho-Tyrosine Mouse mAb (P-Tyr-100) #9411 (lower).

PDGF Receptor β (2B3) Mouse mAb - 3175 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 2B3
Western blot analysis of NIH-3T3 cell lysates, using PDGF Receptor beta (2B3) Mouse mAb.

PDGF Receptor β Antibody - 3162 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines, using PDGF Receptor β Antibody.

PDGF Receptor β (C82A3) Rabbit mAb - 4564 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C82A3
Western blot analysis of extracts from hSkMC, C2C12 and NIH/3T3 cells using PDGF Receptor β (C82A3) Rabbit mAb.

PDGF Receptor β (28E1) Rabbit mAb - 3169 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 28E1
Western blot analysis of extracts from various cell lines, using PDGF Receptor β (28E1) Rabbit mAb.

PDGFR-β (11H4) - sc-80991 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PDGFR-β (11H4): sc-80991. Western blot analysis of PDGFR-β expression in non-transfected: sc-117752 (A) and human PDGFR-β transfected: sc-114235 (B) 293T whole cell lysates.

PDGFR-β (18A2) - sc-19995 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PDGFR-β (18A2) FITC: sc-19995 FITC. FCM analysis of human peripheral blood leukocytes. Quadrant markers were set based on the isotype control, normal mouse IgG<sub>1</sub>: sc-2855.

PDGFR-β (D-6) - sc-374573 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PDGFR-β (D-6): sc-374573. Western blot analysis of PDGFR-β expression in PDGF-BB treated NIH/3T3 whole cell lysate.

PDGFR-β (958) - sc-432 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PDGFR-β (958): sc-432. Western blot analysis of PDGFR-β expression in CCD-1064Sk whole cell lysate.

PDGFR-β (M-20) - sc-1627 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of PDGFR-β expression in rodent 3611-RF (A,C) and human CCD-1064Sk (B,D) fibroblast cell lines. Antibodies tested include PDGFR-β (P-20)-G: sc-339-G (A,B) and PDGFR-β (M-20): sc-1627 (C,D).

PDGFR-β (P-20) - sc-339 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of PDGFR-β expression in rodent 3611-RF (A,C) and human CCD-1064Sk (B,D) fibroblast cell lines. Antibodies tested include PDGFR-β (P-20)-G: sc-339-G (A,B) and PDGFR-β (M-20): sc-1627 (C,D).

p-PDGFR-β (F-10) - sc-365464 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of PDGFR-β phosphorylation in untreated (A,D), PDGFββ treated (B,E) and PDGFββ and lambda protein phosphatase (sc-200312A) treated (C,F) NIH/3T3 whole cell lysates. Antibodies tested include p-PDGFR-β (F-10): sc-365464 (A,B,C) and PDGFR-β (11H4): sc-80991 (D,E,F).

p-PDGFR-β (H-3) - sc-365465 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of PDGFR-β phosphorylation in untreated (A,D), PDGFββ treated (B,E) and PDGFββ and lambda protein phosphatase (sc-200312A) treated (C,F) NIH/3T3 whole cell lysates. Antibodies tested include p-PDGFR-β (H-3): sc-365465 (A,B,C) and PDGFR-β (11H4): sc-80991 (D,E,F).

p-PDGFR-β (H-8) - sc-373805 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of PDGFR-β phosphorylation in non-transfected: sc-117752 (A,D), untreated human PDGFR-β transfected: sc-159386 (B,E) and lambda protein phosphatase (sc-200312A) treated human PDGFR-β transfected: sc-159386 (C,F) 293T whole cell lysates. Antibodies tested include p-PDGFR-β (H-8): sc-373805 (A,B,C) and PDGFR-β (11H4): sc-80991 (D,E,F).

p-PDGFR-β (Tyr 1009) - sc-12908 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-PDGFR-β (Tyr 1009)-R: sc-12908-R. Western blot analysis of PDGFR-β phosphorylation in control (A) and PDGF-BB stimulated (B) CCD-1064Sk whole cell lysates.

p-PDGFR-β (Tyr 1021)-R - sc-12909-R from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
Western blot detection of PDGFR-β phosphorylation in CCD-1064Sk cells (A,C) and CCD-1064Sk cells + PDGF (B,D). Blots were probed with p-PDGFR-β (Tyr 857)-R: sc-12907-R (A,B) and p-PDGFR-β (Tyr 1021)-R: sc-12909-R (C,D).

p-PDGFR-β (Tyr 716) - sc-16569 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of PDGFR-β phosphorylation in untreated (A,D), PDGF treated (B,E) and PDGF and lambda protein phosphatase treated (C,F) NIH/3T3 whole cell lysates. Antibodies tested include p-PDGFR-β (Tyr 716)-R: sc-16569-R (A,B,C) and PDGFR-β (11H4): sc-80991 (D,E,F).

p-PDGFR-β (Tyr 740) - sc-17173 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-PDGFR-β (Tyr 740): sc-17173. Western blot analysis of PDGFR-β phosphorylation in non-transfected: sc-117752 (A) and human PDGFR-β transfected: sc-159386 (B) 293T whole cell lysates.
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