CYP1B1

Gene Symbol	CYP1B1
Entrez Gene	1545
Alt Symbol	CP1B, CYPIB1, GLC3A, P4501B1
Species	Human
Gene Type	protein-coding
Description	cytochrome P450, family 1, subfamily B, polypeptide 1
Other Description	aryl hydrocarbon hydroxylase|cytochrome P450 1B1|cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile)|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
Swissprots	Q9H316 Q93089 Q5TZW8 Q16678
Accessions	AAC50809 AAG43404 AAM50512 AAQ87875 AAY34975 ABC95161 ABD16216 ACL81474 ACL81475 ACL81476 ACL81477 ACL81478 ACL81479 ACO37434 ACO37435 ACO37436 ACX36926 ACX36927 ACX36928 ACX36929 EAX00382 EAX00383 Q16678 AK297039 BAG59567 AK303862 BAG64801 AK312686 BAG35566 BC012049 AAH12049 BP326939 BT019979 AAV38782 BT020001 AAV38804 DA662236 JF432813 ADZ16030 U03688 AAA19567 NM_000104 NP_000095
Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta- estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/o
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion {ECO:0000250}.
Tissue Specificity	Expressed in many tissues. {ECO:0000269|PubMed:8175734}.
Top Pathways	Steroid hormone biosynthesis, Chemical carcinogenesis, Ovarian steroidogenesis, MicroRNAs in cancer, Tryptophan metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CYP1B1 ELISA Kit (Sandwich ELISA) - LS-F7446 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.59 ng/ml Range 1.56-100 ng/ml

Rat CYP1B1 ELISA Kit (Competitive EIA) - LS-F11189 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.625 Range 1.56-100 ng/ml

Human Cytochrome P450 1B1 ELISA Kit - abx151241 from Abbexa Category ELISA Kit Sensitivity 0.61 ng/ml Range 1.563 ng/ml - 100 ng/ml

Cytochrome P450, family 1, subfamily B, polypeptide 1, CYP1B1, Human, ELISA Kit - E-EL-H0384 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Cytochrome P450 1B1 (CYP1B1), Human, ELISA Kit - SED297Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.063ng/mL Range 0.156-10ng/mL

Cytochrome P450 1B1 (CYP1B1), Human, ELISA Kit - E01C2227 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0ng/ml Range 5.0-100ng/ml

Cytochrome P450 1B1, CYP1B1, Human, ELISA Kit - E10140h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Cytochrome P450 1B1, CYP1B1, Rabbit, ELISA Kit - E-EL-RB1643 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cytochrome P450 1B1, CYP1B1, Chicken, ELISA Kit - E-EL-Ch0949 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Cytochrome P450 1B1, CYP1B1, Porcine, ELISA Kit - E-EL-P1068 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cytochrome P450 1B1, CYP1B1, Sheep, ELISA Kit - E-EL-S0886 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Cytochrome P450 1B1, CYP1B1, Guinea Pig, ELISA Kit - E-EL-GP0593 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cytochrome P450 1B1, CYP1B1, Monkey, ELISA Kit - E-EL-MK1706 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human CYP1B1(Cytochrome P450, family 1, subfamily B, polypeptide 1) ELISA Kit - E-EL-H0384 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human CYP1B1 (Cytochrome P450, family 1, subfamily B, polypeptide 1) CLIA Kit - E-CL-H0312 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

CYP1B1, ELISA Kit - MBS2501641 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 4.688ng/mL Range 7.813-500ng/mL

CYP1B1, ELISA Kit - MBS2516095 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Rat CYP1B1 is 0.469ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 0.781-50ng/mL

CYP1B1, ELISA Kit - MBS2514576 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

CYP1B1, ELISA Kit - MBS2511769 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

CYP1B1, ELISA Kit - MBS2503324 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 4.688ng/mL Range 7.813-500ng/mL

CYP1B1, ELISA Kit - MBS2514080 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156--10ng/mL

CYP1B1, ELISA Kit - MBS2508717 from MyBioSource Category ELISA Kit Prices $490.00, $585.00, $2,475.00, $4,360.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/mL Range 0.781-50ng/mL

CYP1B1, ELISA Kit - MBS2507215 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

Cytochrome P450 1B1, ELISA Kit - MBS095013 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytochrome P450 1B1, ELISA Kit - MBS052812 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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