CYP1B1

Gene Symbol	CYP1B1
Entrez Gene	1545
Alt Symbol	CP1B, CYPIB1, GLC3A, P4501B1
Species	Human
Gene Type	protein-coding
Description	cytochrome P450, family 1, subfamily B, polypeptide 1
Other Description	aryl hydrocarbon hydroxylase\|cytochrome P450 1B1\|cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile)\|flavoprotein-linked monooxygenase\|microsomal monooxygenase\|xenobiotic monooxygenase
Swissprots	Q9H316 Q93089 Q5TZW8 Q16678
Accessions	AAC50809 AAG43404 AAM50512 AAQ87875 AAY34975 ABC95161 ABD16216 ACL81474 ACL81475 ACL81476 ACL81477 ACL81478 ACL81479 ACO37434 ACO37435 ACO37436 ACX36926 ACX36927 ACX36928 ACX36929 EAX00382 EAX00383 Q16678 AK297039 BAG59567 AK303862 BAG64801 AK312686 BAG35566 BC012049 AAH12049 BP326939 BT019979 AAV38782 BT020001 AAV38804 DA662236 JF432813 ADZ16030 U03688 AAA19567 NM_000104 NP_000095
Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta- estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/o
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion {ECO:0000250}.
Tissue Specificity	Expressed in many tissues. {ECO:0000269\|PubMed:8175734}.
Top Pathways	Steroid hormone biosynthesis, Chemical carcinogenesis, Ovarian steroidogenesis, MicroRNAs in cancer, Tryptophan metabolism

CYP1B1 (G-4) - sc-374228 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

CYP1B1 (G-4): sc-374228. Western blot analysis of CYP1B1 expression in non-transfected: sc-117752 (A) and human CYP1B1 transfected: sc-158414 (B) 293T whole cell lysates.

CYP1B1 (A-15) - sc-31666 from Santa Cruz Biotechnology

Host	Goat
Clonality	Polyclonal

CYP1B1 (F-16) - sc-31667 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CYP1B1 (F-16): sc-31667. Western blot analysis of CYP1B1 expression in mouse kidney tissue extract.

CYP1B1 (H-105) - sc-32882 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

CYP1B1 (H-105): sc-32882. Western blot analysis of CYP1B1 expression in non-transfected: sc-117752 (A) and human CYP1B1 transfected: sc-158414 (B) 293T whole cell lysates.

CYP1B1 (G-25) - sc-133490 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/0.5 ml
Host	Rabbit
Clonality	Polyclonal

CYP1B1 (G-25): sc-133490. Western blot analysis of CYP1B1 expression in human fetal liver tissue extract.

Anti-CYP1B1 antibody - ab33586 from Abcam

Prices	$392.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Lane 1 : MarkerLane 2 : Anti-CYP1B1 antibody (ab33586) at 1 µg/mlLane 1 : As aboveLane 2 : Human brain tissue lysate at 10 µgSecondaryLane 2 : IRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/15000 dilutionPerformed under reducing conditions.

Anti-CYP1B1 antibody - ab32649 from Abcam

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CYP1B1 antibody (ab32649) at 1 µg/mlLane 1 : Brain (Human) Tissue Lysate - adult normal tissueLane 2 : Kidney (Human) Tissue Lysate - adult normal tissueLane 3 : Liver (Human) Tissue Lysate - adult normal tissueLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CYP1B1 antibody - ab137562 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CYP1B1 antibody (ab137562) at 1/3000 dilution + HeLa S3 whole cell lysate at 30 µg

Anti-CYP1B1 antibody - ab80224 from Abcam

Prices	$304.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CYP1B1 antibody (ab80224) at 1/50 dilution + CEM cell line lysate at 35 µg

Anti-CYP1B1 antibody [EPR14972] - C-terminal - ab185954 from Abcam

Prices	$384.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR14972

All lanes : Anti-CYP1B1 antibody [EPR14972] - C-terminal (ab185954) at 1/20000 dilutionLane 1 : Human breast cancer lysateLane 2 : Human fetal kidney lysateLysates/proteins at 20 µg per lane.SecondaryAnti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Anti-CYP1B1 antibody - C-terminal - ab87487 from Abcam

Host	Rabbit
Clonality	Polyclonal

Anti-CYP1B1 Antibody (aa200-250) IHC-plus™ - LS-B1804 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP1B1 antibody IHC of mouse heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1804 concentration 10 ug/ml.

Anti-CYP1B1 Antibody (aa200-249) - LS-C81663 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Fetal liver cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.

Anti-CYP1B1 Antibody (Internal) - LS-C99445 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Western blot of anti-CYP1B1 Antibody in CEM cell line lysates (35 ug/lane). CYP1B1(arrow) was detected using the purified antibody.

Anti-CYP1B1 Antibody (aa374-516, Biotin) - LS-C299599 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP1B1 Antibody (aa374-516, FITC) - LS-C303665 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP1B1 Antibody (aa452-497) - LS-C313726 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP1B1 Antibody (aa294-343) - LS-C170217 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP1B1 Antibody (clone 2F8) - LS-C197010 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	2F8

Detection limit for recombinant GST tagged CYP1B1 is approximately 0.3 ng/ml as a capture antibody.

Anti-CYP1B1 Antibody - LS-C192746 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Western blot of extracts of CEM cell lines, using CYP1B1 antibody.

Anti-CYP1B1 Antibody (aa374-516) - LS-C293631 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP1B1 Antibody - LS-C331436 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of CEM cell lines, using CYP1B1 antibody.

Anti-CYP1B1 Antibody (aa400-450) IHC-plus™ - LS-B1790 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP1B1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1790 concentration 10 ug/ml.

CYP1B1 Antibody - NBP2-24722 from Novus Biologicals

Prices	$99.00, $229.00
Sizes	25 µg, 100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: CYP1B1 Antibody [NBP2-24722] - Analysis of CYP1B1 in human brain lysate in the 1) absence and 2) presence of immunizing peptide using this antibody at 1 ug/ml.

CYP1B1 Antibody - NBP1-85496 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Search more