CYP1B1

Gene Symbol	CYP1B1
Entrez Gene	1545
Alt Symbol	CP1B, CYPIB1, GLC3A, P4501B1
Species	Human
Gene Type	protein-coding
Description	cytochrome P450, family 1, subfamily B, polypeptide 1
Other Description	aryl hydrocarbon hydroxylase|cytochrome P450 1B1|cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile)|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
Swissprots	Q9H316 Q93089 Q5TZW8 Q16678
Accessions	AAC50809 AAG43404 AAM50512 AAQ87875 AAY34975 ABC95161 ABD16216 ACL81474 ACL81475 ACL81476 ACL81477 ACL81478 ACL81479 ACO37434 ACO37435 ACO37436 ACX36926 ACX36927 ACX36928 ACX36929 EAX00382 EAX00383 Q16678 AK297039 BAG59567 AK303862 BAG64801 AK312686 BAG35566 BC012049 AAH12049 BP326939 BT019979 AAV38782 BT020001 AAV38804 DA662236 JF432813 ADZ16030 U03688 AAA19567 NM_000104 NP_000095
Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta- estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/o
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion {ECO:0000250}.
Tissue Specificity	Expressed in many tissues. {ECO:0000269|PubMed:8175734}.
Top Pathways	Steroid hormone biosynthesis, Chemical carcinogenesis, Ovarian steroidogenesis, MicroRNAs in cancer, Tryptophan metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CYP1B1 peptide - ab33584 from Abcam Category Peptide

Human CYP1B1 peptide - ab33585 from Abcam Category Peptide

Human CYP1B1 protein fragment - ab114353 from Abcam Category Protein Source Wheat germ Species Human

CYP1B1 Antibody Blocking Peptide - LS-E18557 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYP1B1 Antibody Blocking Peptide - LS-E18558 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYP1B1 Antibody Blocking Peptide - LS-E9350 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CYP1B1 Protein - H00001545-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CYP1B1-Antibody-Center-Blocking-Peptide - BP7891c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CYP1B1 Blocking Peptide - 33R-1584 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Cytochrome P450 1B1 Blocking Peptide - abx062502 from Abbexa Category Peptide Species Human, Mouse, Rat

Human Cytochrome P450 1B1 Protein - abx066252 from Abbexa Category Protein Source E.coli Species Human

CYP1B1 - H00001545-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CYP1B1 - H00001545-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Cytochrome P450 1B1 (CYP1B1), Human - 20-8736 from ARP American Research Products Category Protein Prices $569.00 Sizes 50 µg Source E.coli Species Human

CYP1B1 fusion protein - ag13357 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CYP1B1 fusion protein - ag13380 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human CYP1B1 - CYP1B1-28190TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human CYP1B1 - CYP1B1-552H from Creative Biomart Category Protein Source baculovirus infected insect cells Species Human

Recombinant Cytochrome P450 1B1 (CYP1B1) - RPD297Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Cytochrome P450 1B1 Blocking Peptide - CBP1308 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

CYP1B1 Peptide - BS5681P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Cytochrome P450 1B1 (CYP1B1) - RPD297Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Cytochrome P450 1B1(CYP1B1) - CSB-YP618091HU CSB-EP618091HU CSB-BP618091HU CSB-MP618091HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Cytochrome P450 1B1 (CYP1B1) - RPU141123 from Biomatik Category Protein Prices $275.00, $550.00, $825.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Human

CYP1B1 Recombinant Protein Antigen - NBP1-85496PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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