| Gene Symbol | CYP1B1 |
|---|---|
| Entrez Gene | 1545 |
| Alt Symbol | CP1B, CYPIB1, GLC3A, P4501B1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| Other Description | aryl hydrocarbon hydroxylase|cytochrome P450 1B1|cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile)|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase |
| Swissprots | Q9H316 Q93089 Q5TZW8 Q16678 |
| Accessions | AAC50809 AAG43404 AAM50512 AAQ87875 AAY34975 ABC95161 ABD16216 ACL81474 ACL81475 ACL81476 ACL81477 ACL81478 ACL81479 ACO37434 ACO37435 ACO37436 ACX36926 ACX36927 ACX36928 ACX36929 EAX00382 EAX00383 Q16678 AK297039 BAG59567 AK303862 BAG64801 AK312686 BAG35566 BC012049 AAH12049 BP326939 BT019979 AAV38782 BT020001 AAV38804 DA662236 JF432813 ADZ16030 U03688 AAA19567 NM_000104 NP_000095 |
| Function | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta- estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/o |
| Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion {ECO:0000250}. |
| Tissue Specificity | Expressed in many tissues. {ECO:0000269|PubMed:8175734}. |
| Top Pathways | Steroid hormone biosynthesis, Chemical carcinogenesis, Ovarian steroidogenesis, MicroRNAs in cancer, Tryptophan metabolism |