| Gene Symbol | BUB1B |
|---|---|
| Entrez Gene | 701 |
| Alt Symbol | BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | BUB1 mitotic checkpoint serine/threonine kinase B |
| Other Description | MAD3/BUB1-related protein kinase|budding uninhibited by benzimidazoles 1 homolog beta|mitotic checkpoint kinase MAD3L|mitotic checkpoint serine/threonine-protein kinase BUB1 beta |
| Swissprots | O60627 O60501 B4DLG3 O60566 Q8WV50 B4DL09 O75389 Q59HH6 O60758 Q96KM4 B2R6U0 |
| Accessions | AAL10712 ADF57218 EAW92394 O60566 AB208782 BAD92019 AF035933 AAC23736 AF046079 AAC12730 AF046918 AAC33435 AF053306 AAC06260 AF068760 AAC19118 AF107297 AAD11941 AI742619 AK296795 BAG59371 AK296984 BAG59525 AK312709 BAG35587 AL597325 BC018739 AAH18739 JF432304 ADZ15521 NM_001211 NP_001202 |
| Function | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| Subcellular Location | Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and CASC5. |
| Tissue Specificity | Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index. {ECO:0000269|PubMed:10593653}. |
| Top Pathways | Cell cycle, HTLV-I infection |