BUB1B

Gene Symbol	BUB1B
Entrez Gene	701
Alt Symbol	BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1
Species	Human
Gene Type	protein-coding
Description	BUB1 mitotic checkpoint serine/threonine kinase B
Other Description	MAD3/BUB1-related protein kinase|budding uninhibited by benzimidazoles 1 homolog beta|mitotic checkpoint kinase MAD3L|mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Swissprots	O60627 O60501 B4DLG3 O60566 Q8WV50 B4DL09 O75389 Q59HH6 O60758 Q96KM4 B2R6U0
Accessions	AAL10712 ADF57218 EAW92394 O60566 AB208782 BAD92019 AF035933 AAC23736 AF046079 AAC12730 AF046918 AAC33435 AF053306 AAC06260 AF068760 AAC19118 AF107297 AAD11941 AI742619 AK296795 BAG59371 AK296984 BAG59525 AK312709 BAG35587 AL597325 BC018739 AAH18739 JF432304 ADZ15521 NM_001211 NP_001202
Function	Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}.
Subcellular Location	Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and CASC5.
Tissue Specificity	Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index. {ECO:0000269|PubMed:10593653}.
Top Pathways	Cell cycle, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Bub1b siRNA II - 12150 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® Bub1b siRNA I - 6623 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

BUBR1 CRISPR/Cas9 KO Plasmid (h) - sc-403807 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

BUBR1 HDR Plasmid (h) - sc-403807-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BUBR1 Double Nickase Plasmid (h) - sc-403807-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BUBR1 Double Nickase Plasmid (h2) - sc-403807-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BUBR1 CRISPR Activation Plasmid (h) - sc-403807-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

BUBR1 CRISPR Activation Plasmid (h2) - sc-403807-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

BUBR1 Lentiviral Activation Particles (h) - sc-403807-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BUBR1 Lentiviral Activation Particles (h2) - sc-403807-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BUBR1 siRNA (h) - sc-37542 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

BUBR1 shRNA Plasmid (h) - sc-37542-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

BUBR1 shRNA (h) Lentiviral Particles - sc-37542-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

BubR1 RNAi - H00000701-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

BubR1 RNAi - H00000701-R02 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU052101 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0211 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0210 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0212 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN4120 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4120 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

BUB1B siRNA (Human) - CRH0486 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

BUB1B - MBS8204176 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human BUB1B (NM_001211.5) - SHH248446 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human BUB1B(NM_001211.5) - SHG108181 from Creative biogene Category siRNA Species Reactivities Human

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