BUB1B

Gene Symbol	BUB1B
Entrez Gene	701
Alt Symbol	BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1
Species	Human
Gene Type	protein-coding
Description	BUB1 mitotic checkpoint serine/threonine kinase B
Other Description	MAD3/BUB1-related protein kinase|budding uninhibited by benzimidazoles 1 homolog beta|mitotic checkpoint kinase MAD3L|mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Swissprots	O60627 O60501 B4DLG3 O60566 Q8WV50 B4DL09 O75389 Q59HH6 O60758 Q96KM4 B2R6U0
Accessions	AAL10712 ADF57218 EAW92394 O60566 AB208782 BAD92019 AF035933 AAC23736 AF046079 AAC12730 AF046918 AAC33435 AF053306 AAC06260 AF068760 AAC19118 AF107297 AAD11941 AI742619 AK296795 BAG59371 AK296984 BAG59525 AK312709 BAG35587 AL597325 BC018739 AAH18739 JF432304 ADZ15521 NM_001211 NP_001202
Function	Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}.
Subcellular Location	Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and CASC5.
Tissue Specificity	Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index. {ECO:0000269|PubMed:10593653}.
Top Pathways	Cell cycle, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human BubR1 protein fragment - ab133149 from Abcam Category Protein Prices $352.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human BubR1 full length protein - ab114248 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Human BubR1 protein fragment - ab114249 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

BUB1B / BubR1 Antibody Blocking Peptide - LS-E9460 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human BubR1 Protein - H00000701-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human BubR1 Protein - H00000701-P01 from Novus Biologicals Category Protein Prices $325.00, $475.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

BubR1 Peptide - P3050 from Novus Biologicals Category Peptide Species Human

BUBR1-BUB1B-Antibody-N-term-Blocking-peptide - BP8059a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BUB1B - H00000701-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BUB1B - H00000701-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BUB1B - H00000701-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BUB1B - H00000701-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BUB1B - P5502 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

BUB1B fusion protein - Ag2053 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human BUB1B - BUB1B-26124TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human BUB1B - BUB1B-27105TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human BUB1B, GST-tagged - BUB1B-10335H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human BUB1B (Active), GST-tagged - BUB1B-1371H from Creative Biomart Category Protein Source Sf9 Cells Species Human

BUB1B (T368) Peptide - BS2244P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Mitotic checkpoint serine/threonine-protein kinase BUB1 beta(B - CSB-YP002883HU CSB-EP002883HU CSB-BP002883HU CSB-MP002883HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

BUB1B - TP305844 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

BubR1 Protein - NBP1-89920PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

BUB1B-Antibody-N-term-Blocking-Peptide - BP8059d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BUB1B-Antibody-Center-Blocking-Peptide - BP8059b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BUB1B Peptide, Human - M34GP01596H from Creative Peptides Category Peptide Source Synthetic. Species Human

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