| Gene Symbol |
UGT1A8
|
| Entrez Gene |
54576
|
| Alt Symbol |
UDPGT, UDPGT 1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UDP glucuronosyltransferase 1 family, polypeptide A8
|
| Other Description |
UDP glycosyltransferase 1 family, polypeptide A8|UDP-glucuronosyltransferase 1 family polypeptide A8s|UDP-glucuronosyltransferase 1-8|UDP-glucuronosyltransferase 1-H|UDP-glucuronosyltransferase 1A8
|
| Swissprots |
Q8WX85 Q8TEX4 Q9HAW9 Q8WTQ9 B8K290 B2R8S3 O14928
|
| Accessions |
AAA86625 AAG30416 AAL73506 AAL73507 AAL73508 AAX47026 AAX47027 AAX47028 AAX47029 AAX47030 AAX47031 AAX47032 AAY24023 EAW71057 Q9HAW9 AF030310 AAB84259 AF462267 AAL75963 AF462268 AAL75964 AK313488 BAG36270 AY435143 AAR95644 BC156848 AAI56849 DQ364251 ABC96775 NM_019076 NP_061949
|
| Function |
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:19545173}.
|
| Subcellular Location |
Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Colon specific. Isoform 1 and 2 are expressed in liver, kidney, colon and small intestine; isoform 2 but not isoform 1 is expressed in liver (PubMed:18004212). {ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:9535849}.
|
| Top Pathways |
Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450
|