TAOK2

Gene Symbol TAOK2
Entrez Gene 9344
Alt Symbol MAP3K17, PSK, PSK1, PSK1-BETA, TAO1, TAO2
Species Human
Gene Type protein-coding
Description TAO kinase 2
Other Description PSK-1|hKFC-C|kinase from chicken homolog C|prostate derived STE20-like kinase PSK|prostate-derived STE20-like kinase 1|prostate-derived sterile 20-like kinase 1|serine/threonine-protein kinase TAO2|thousand and one amino acid protein kinase 2
Swissprots B7ZM88 Q6UW73 A5PKY1 Q9UL54 O94957 Q9NSW2 B2RN35 A7MCZ2 Q7LC09
Accessions EAW79963 EAW79964 EAW79965 Q9UL54 AB020688 BAA74904 AF061943 AAD45616 AF263313 AAG38503 AI805725 AK057589 AK291473 BAF84162 AK304446 BAG65265 AL137701 CAB70882 AY358942 AAQ89301 BC015204 AAH15204 BC031825 AAH31825 BC051798 AAH51798 BC054495 BC136653 AAI36654 BC136655 AAI36656 BC142663 AAI42664 BC144344 AAI44345 BC151221 AAI51222 BC152413 AAI52414 BP233788 CN286840 XM_011545982 XP_011544284 XM_011545983 XP_011544285 XM_011545984 XP_011544286 XM_011545985 XP_011544287 XM_011545986 XP_011544288 XM_011545987 XP_011544289 XM_011545988 XP_011544290 XM_011545989 XP_011544291 XR_950873 NM_001252043 NP_001238972 NM_004783 NP_004774 NM_016151 NP_057235
Function Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubul
Subcellular Location Cytoplasmic vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton. Nucleus. Note=Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full- length isoform 1 are excluded from the nucleus.
Tissue Specificity Ubiquitously expressed, with a higher level of expression in testis and brain. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:13679851}.
Top Pathways MAPK signaling pathway

PSK2 (22) - sc-136094 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
PSK2 (22): sc-136094. Western blot analysis of PSK2 expression in rat cerebrum tissue extract.

TAO2 (C-2) - sc-514268 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TAO2 (C-2): sc-514268. Western blot analysis of TAO2 expression in NTERA-2 cl.D1 (A), HEK293 (B) and HL-60 (C) whole cell lysates.

TAO2 (H-8) - sc-514254 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TAO2 (H-8): sc-514254. Western blot analysis of TAO2 expression in HEK293 (A) and HL-60 (B) whole cell lysates.

TAO2 (N-14) - sc-47449 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TAO2 (K-16) - sc-47447 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TAO2 (K-16): sc-47447. Western blot analysis of TAO2 expression in PC-12 whole cell lysate (A) and rat hypothalamus (B) and mouse brain (C) tissue extracts.

TAO2 (H-59) - sc-135258 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TAO2 (H-52) - sc-366021 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TAO2 (L-30) - sc-100444 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µl ascites
Host Mouse
Clonality Monoclonal
TAO2 (L-30): sc-100444. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tissue showing cytoplasmic localization.

p-TAO2 (Ser 181) - sc-135712 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
p-TAO2 (Ser 181): sc-135712. Western blot analysis of TAO2 phosphorylation in untreated (A) and lambda protein phosphatase-treated (B) rat prefrontal cortex tissue extracts.

Anti-TAO kinase 2 (phospho S181) antibody - ab32591 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-TAO kinase 2 (phospho S181) antibody (ab32591) at 1/1000 dilution + Rat hippocampal lysates

Anti-TAO kinase 2 antibody - ab173340 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TAO kinase 2 antibody (ab173340) at 1/100 dilution + HL60 cell line lysate at 35 µg

Anti-TAO kinase 2 antibody - N-terminal - ab155595 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TAO kinase 2 antibody - N-terminal (ab155595) at 1/1000 dilution + Mouse brain whole cell lysate at 50 µg

Anti-TAO kinase 2 antibody - ab56571 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56571 TAO antibody at 1ug/ml.

Anti-TAOK2 / TAO2 Antibody (aa765-780) - LS-C147887 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-TAOK2 / TAO2 Antibody (aa414-443, AP) - LS-C241528 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TAOK2 / TAO2 Antibody (phospho-Ser181) - LS-C182550 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-TAOK2 / TAO2 Antibody (aa414-443, FITC) - LS-C241530 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TAOK2 / TAO2 Antibody (aa414-443, APC) - LS-C241529 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TAOK2 / TAO2 Antibody (aa415-443) - LS-C164587 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Mouse Taok2 Antibody western blot of HL-60 cell line lysates (35 ug/lane). The Taok2 antibody detected the Taok2 protein (arrow).

Anti-TAOK2 / TAO2 Antibody - LS-C335331 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using TAOK2 antibody.

Anti-TAOK2 / TAO2 Antibody (clone 2E2) IHC-plus™ - LS-B4484 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2E2
Anti-TAOK2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4484 concentration 5 ug/ml.

Anti-TAOK2 / TAO2 Antibody (aa414-443, Biotin) - LS-C241531 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TAOK2 / TAO2 Antibody (aa414-443, Azide-free, HRP) - LS-C248305 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TAOK2 / TAO2 Antibody (aa414-443, PE) - LS-C241533 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TAOK2 / TAO2 Antibody (aa414-443) - LS-C330202 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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