| Gene Symbol |
TAOK2
|
| Entrez Gene |
9344
|
| Alt Symbol |
MAP3K17, PSK, PSK1, PSK1-BETA, TAO1, TAO2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TAO kinase 2
|
| Other Description |
PSK-1|hKFC-C|kinase from chicken homolog C|prostate derived STE20-like kinase PSK|prostate-derived STE20-like kinase 1|prostate-derived sterile 20-like kinase 1|serine/threonine-protein kinase TAO2|thousand and one amino acid protein kinase 2
|
| Swissprots |
B7ZM88 Q6UW73 A5PKY1 Q9UL54 O94957 Q9NSW2 B2RN35 A7MCZ2 Q7LC09
|
| Accessions |
EAW79963 EAW79964 EAW79965 Q9UL54 AB020688 BAA74904 AF061943 AAD45616 AF263313 AAG38503 AI805725 AK057589 AK291473 BAF84162 AK304446 BAG65265 AL137701 CAB70882 AY358942 AAQ89301 BC015204 AAH15204 BC031825 AAH31825 BC051798 AAH51798 BC054495 BC136653 AAI36654 BC136655 AAI36656 BC142663 AAI42664 BC144344 AAI44345 BC151221 AAI51222 BC152413 AAI52414 BP233788 CN286840 XM_011545982 XP_011544284 XM_011545983 XP_011544285 XM_011545984 XP_011544286 XM_011545985 XP_011544287 XM_011545986 XP_011544288 XM_011545987 XP_011544289 XM_011545988 XP_011544290 XM_011545989 XP_011544291 XR_950873 NM_001252043 NP_001238972 NM_004783 NP_004774 NM_016151 NP_057235
|
| Function |
Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubul
|
| Subcellular Location |
Cytoplasmic vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton. Nucleus. Note=Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full- length isoform 1 are excluded from the nucleus.
|
| Tissue Specificity |
Ubiquitously expressed, with a higher level of expression in testis and brain. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:13679851}.
|
| Top Pathways |
MAPK signaling pathway
|
![Western Blot: TAO Kinase 2 Overexpression Lysate (Adult Normal) [NBL1-16697] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TAO Kinase 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9531_TAO%2520Kinase%25202%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16697-img0002.jpg)