TAOK2

Gene Symbol	TAOK2
Entrez Gene	9344
Alt Symbol	MAP3K17, PSK, PSK1, PSK1-BETA, TAO1, TAO2
Species	Human
Gene Type	protein-coding
Description	TAO kinase 2
Other Description	PSK-1|hKFC-C|kinase from chicken homolog C|prostate derived STE20-like kinase PSK|prostate-derived STE20-like kinase 1|prostate-derived sterile 20-like kinase 1|serine/threonine-protein kinase TAO2|thousand and one amino acid protein kinase 2
Swissprots	B7ZM88 Q6UW73 A5PKY1 Q9UL54 O94957 Q9NSW2 B2RN35 A7MCZ2 Q7LC09
Accessions	EAW79963 EAW79964 EAW79965 Q9UL54 AB020688 BAA74904 AF061943 AAD45616 AF263313 AAG38503 AI805725 AK057589 AK291473 BAF84162 AK304446 BAG65265 AL137701 CAB70882 AY358942 AAQ89301 BC015204 AAH15204 BC031825 AAH31825 BC051798 AAH51798 BC054495 BC136653 AAI36654 BC136655 AAI36656 BC142663 AAI42664 BC144344 AAI44345 BC151221 AAI51222 BC152413 AAI52414 BP233788 CN286840 XM_011545982 XP_011544284 XM_011545983 XP_011544285 XM_011545984 XP_011544286 XM_011545985 XP_011544287 XM_011545986 XP_011544288 XM_011545987 XP_011544289 XM_011545988 XP_011544290 XM_011545989 XP_011544291 XR_950873 NM_001252043 NP_001238972 NM_004783 NP_004774 NM_016151 NP_057235
Function	Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubul
Subcellular Location	Cytoplasmic vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton. Nucleus. Note=Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full- length isoform 1 are excluded from the nucleus.
Tissue Specificity	Ubiquitously expressed, with a higher level of expression in testis and brain. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:13679851}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human TAO kinase 2 protein fragment - ab61426 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human TAO kinase 2 protein fragment - ab160445 from Abcam Category Protein Source Wheat germ Species Human

PSK / SEZ6L2 Antibody Blocking Peptide - LS-E7654 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TAOK2 / TAO2 Antibody Blocking Peptide - LS-E3306 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TAO2 Protein - H00009344-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TAO2 Peptide - P2722 from Novus Biologicals Category Peptide Species Human

TAO-Kinase-2-TAOK2-Antibody-C-term-Blocking-peptide - BP7682a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TAO kinase 2 (TAOK2) - H00009344-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TAO kinase 2 (TAOK2) - H00009344-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TAO kinase 2 (TAOK2) - P5647 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

TAOK2 fusion protein - ag15521 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human TAO Kinase 2, GST-tagged, Active - TAOK2-442H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human TAOK2, GST-tagged - TAOK2-3111H from Creative Biomart Category Protein Source E.coli Species Human

TAO2 Protein, active, 10 µg - 14-736 from EMD Millipore Category Protein Prices $401.00 Sizes 10 µg Source expressed in Sf21 cells

TAO kinase 2 (TAOK2) (transcript variant 1) - TP314344 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

TAO2 Recombinant Protein Antigen - NBP1-81465PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TAO1 Blocking Peptide - abx162054 from Abbexa Category Peptide Species Human, Mouse, Rat

TAO2 Protein, active, 250 µg - 14-736M from EMD Millipore Category Protein Prices $2,842.00 Sizes 250 µg also available in 10 μg size . (cat#14-736) and in bulk (cat# 14-736-K) Source expressed in Sf21 cells

TAO-Kinase-2-Antibody-C-term-Blocking-peptide - BP7954a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TAOK2 Peptide, Human - M34GP15574H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human Serine/threonine-protein kinase TAO2(TAOK2) ,partial,Yeast - CSB-YP892341HU from Cusabio Category Protein Source Yeast Species Human

Serine/threonine-protein kinase TAO2 (TAOK2), Recombinant Protein - MBS7102285 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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