| Gene Symbol | CATSPER1 |
|---|---|
| Entrez Gene | 117144 |
| Alt Symbol | CATSPER, SPGF7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cation channel, sperm associated 1 |
| Other Description | cation channel sperm-associated protein 1|hCatSper|sperm ion channel|sperm-associated cation channel 1 |
| Swissprots | Q8NEC5 Q96P76 |
| Accessions | EAW74488 EAW74489 Q8NEC5 AF407333 AAL14105 BC032950 AAH32950 BC036522 AAH36522 XR_949785 XR_949786 XR_949787 NM_053054 NP_444282 |
| Function | Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}. |
| Subcellular Location | Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:16625279}; Multi-pass membrane protein {ECO:0000269|PubMed:16625279}. Note=Specifically located in the principal piece of sperm tail. |
| Tissue Specificity | Testis-specific. {ECO:0000269|PubMed:11595941, ECO:0000269|PubMed:16625279, ECO:0000269|PubMed:17347248}. |