CATSPER1

Gene Symbol CATSPER1
Entrez Gene 117144
Alt Symbol CATSPER, SPGF7
Species Human
Gene Type protein-coding
Description cation channel, sperm associated 1
Other Description cation channel sperm-associated protein 1|hCatSper|sperm ion channel|sperm-associated cation channel 1
Swissprots Q8NEC5 Q96P76
Accessions EAW74488 EAW74489 Q8NEC5 AF407333 AAL14105 BC032950 AAH32950 BC036522 AAH36522 XR_949785 XR_949786 XR_949787 NM_053054 NP_444282
Function Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.
Subcellular Location Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:16625279}; Multi-pass membrane protein {ECO:0000269|PubMed:16625279}. Note=Specifically located in the principal piece of sperm tail.
Tissue Specificity Testis-specific. {ECO:0000269|PubMed:11595941, ECO:0000269|PubMed:16625279, ECO:0000269|PubMed:17347248}.

CatSper CRISPR/Cas9 KO Plasmid (h) - sc-403796 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper HDR Plasmid (h) - sc-403796-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper Double Nickase Plasmid (h) - sc-403796-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper Double Nickase Plasmid (h2) - sc-403796-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper CRISPR Activation Plasmid (h) - sc-403796-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper CRISPR Activation Plasmid (h2) - sc-403796-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper Lentiviral Activation Particles (h) - sc-403796-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper Lentiviral Activation Particles (h2) - sc-403796-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper siRNA (h) - sc-42375 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CatSper shRNA Plasmid (h) - sc-42375-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CatSper shRNA (h) Lentiviral Particles - sc-42375-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CATSPER1 RNAi - H00117144-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU000901 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2521 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2521 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CATSPER1 siRNA (Human) - CRJ4548 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CATSPER1 - MBS8211024 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CatSper CRISPR/Cas9 KO Plasmid (h2) - sc-403796-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CatSper HDR Plasmid (h2) - sc-403796-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human CATSPER1 (NM_053054.3) - SHH255141 from Creative biogene

Category siRNA
Species Reactivities Human

CATSPER1 shRNA Plasmid (Human) - CHJ4548 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CATSPER1 miRNA 3'UTR clone - MiUTR4H-TG01647 from Creative biogene

Species Reactivities Human
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