CATSPER1

Gene Symbol	CATSPER1
Entrez Gene	117144
Alt Symbol	CATSPER, SPGF7
Species	Human
Gene Type	protein-coding
Description	cation channel, sperm associated 1
Other Description	cation channel sperm-associated protein 1|hCatSper|sperm ion channel|sperm-associated cation channel 1
Swissprots	Q8NEC5 Q96P76
Accessions	EAW74488 EAW74489 Q8NEC5 AF407333 AAL14105 BC032950 AAH32950 BC036522 AAH36522 XR_949785 XR_949786 XR_949787 NM_053054 NP_444282
Function	Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.
Subcellular Location	Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:16625279}; Multi-pass membrane protein {ECO:0000269|PubMed:16625279}. Note=Specifically located in the principal piece of sperm tail.
Tissue Specificity	Testis-specific. {ECO:0000269|PubMed:11595941, ECO:0000269|PubMed:16625279, ECO:0000269|PubMed:17347248}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CATSPER1 full length protein - ab165120 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human CATSPER1 protein fragment - ab165121 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CATSPER1 / CATSPER Antibody Blocking Peptide - LS-E2101 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CATSPER1 Protein - H00117144-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CATSPER1 Protein - H00117144-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

CATSPER1-Antibody-N-term-Blocking-peptide - BP12995a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CATSPER1 Blocking Peptide - abx161049 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

CATSPER1 - H00117144-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CATSPER1 - H00117144-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CATSPER1 fusion protein - ag4388 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

CATSPER1 fusion protein - Ag3417 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human CATSPER1, GST-tagged - CATSPER1-10746H from Creative Biomart Category Protein Source E.coli Species Human

CATSPER1 Blocking Peptide - CBP3548 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

CATSPER1 Peptide, Human - M34GP02409H from Creative Peptides Category Peptide Source Synthetic. Species Human

CATSPER1 peptide - orb234423 from Biorbyt Category Peptide Prices $247.00, $536.00 Sizes 1 mg, 5 mg

Cation channel sperm-associated protein 1 (CATSPER1), Recombinant Protein - MBS7010766 from MyBioSource Category Protein Prices $1,565.00, $2,530.00, $3,755.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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