| Gene Symbol |
Fbxo5
|
| Entrez Gene |
67141
|
| Alt Symbol |
2510044I10Rik, C85305, Emi1, Fbxo31
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
F-box protein 5
|
| Other Description |
F-box only protein 5|early mitotic inhibitor 1|f-box only protein 31|fbxo5
|
| Swissprots |
Q7TSG3
|
| Accessions |
EDL03567 Q7TSG3 AK011820 BAB27861 AK135916 AK160201 BC053434 AAH53434 NM_025995 NP_080271
|
| Function |
Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding. {ECO:0000250|UniProtKB:Q9UKT4, ECO:0000269|PubMed:16809773}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle (By similarity). {ECO:0000250}.
|
| Top Pathways |
Oocyte meiosis
|
